Publication: Flavoenzimlerdeki flavin oksidasyonu mekanizmasının hesapsal modellenmesi
Abstract
Flavoproteinlerde çeşitli enzim mekanizmaları sonucu kataliz sırasında FAD indirgenmektedir. İndirgenmiş flavin aşagıdaki reaksiyona göre moleküler oksijenle reaksiyona girerek tekrar oksitlenir ve enzim tekrar aktif hale gelir. E-FADH2 + O2 → E-FAD + H2O2 Reaksiyon sonunda oluşan hidrojenperoksit bir reaktif oksijen türüdür ve oksidatif strese neden olmaktadır.
As a result of various enzyme mechanisms in the flavoproteins, FAD is reduced during the catalysis. Reduced flavin is reoxidized by reacting with molecular oxygen according to the following reaction and the enzyme becomes active again. E-FADH2 + O2 → E-FAD + H2O2Hydrogen peroxide formed at the end of the reaction is a reactive oxygen species which causes oxidative stress.
As a result of various enzyme mechanisms in the flavoproteins, FAD is reduced during the catalysis. Reduced flavin is reoxidized by reacting with molecular oxygen according to the following reaction and the enzyme becomes active again. E-FADH2 + O2 → E-FAD + H2O2Hydrogen peroxide formed at the end of the reaction is a reactive oxygen species which causes oxidative stress.