Publication:
THE HYPOTENSIVE EFFECT OF CISAPRIDE IN RAT

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsONAT, F; YEGEN, B; BERKMAN, K; OKTAY, S
dc.date.accessioned2022-03-12T16:56:24Z
dc.date.accessioned2026-01-11T06:58:54Z
dc.date.available2022-03-12T16:56:24Z
dc.date.issued1994
dc.description.abstract1. Cisapride is a prokinetic agent believed to facilitate acetylcholine release from the myenteric plexus of the gut. The aim of the present study was to investigate the effect of cisapride on blood pressure and the effects of muscarinic receptor antagonists on the cisapride-induced blood pressure changes. 2. Cisapride was given i.v. alone or 10 min after muscarinic receptor antagonists. Cisapride given i.v. produced a significant decrease in blood pressure in a dose-related manner. Atropine, AF-DX 116 and 4-DAMP given 10 min before cisapride injection, partially inhibited the hypotensive response to cisapride. In pithed rat, the effect of cisapride on blood pressure remained unaltered. 3. This study indicates that the action of cisapride is not through central mechanisms and part of cisapride's effect is through the cholinergic system.
dc.identifier.doi10.1016/0306-3623(94)90146-5
dc.identifier.issn0306-3623
dc.identifier.pubmed7875553
dc.identifier.urihttps://hdl.handle.net/11424/226752
dc.identifier.wosWOS:A1994PQ90200028
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofGENERAL PHARMACOLOGY-THE VASCULAR SYSTEM
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBLOOD PRESSURE
dc.subjectCISAPRIDE
dc.subjectCHOLINERGIC SYSTEM
dc.subjectINTRAVENOUS CISAPRIDE
dc.subjectMOTOR-ACTIVITY
dc.subjectGUINEA-PIG
dc.subjectGASTROPARESIS
dc.subjectCONTRACTION
dc.subjectSTIMULATION
dc.titleTHE HYPOTENSIVE EFFECT OF CISAPRIDE IN RAT
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage1256
oaire.citation.issue6
oaire.citation.startPage1253
oaire.citation.titleGENERAL PHARMACOLOGY-THE VASCULAR SYSTEM
oaire.citation.volume25

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