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Synthesis and antimicrobial activity of some new hydrazones of 4-fluorobenzoic acid hydrazide and 3-acetyl-2,5-disubstituted-1,3,4-oxadiazolines

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dc.contributor.authorsRollas, Sevim; Gulerman, Nehir; Erdeniz, Habibe
dc.date.accessioned2022-03-15T11:25:25Z
dc.date.accessioned2026-01-11T09:00:09Z
dc.date.available2022-03-15T11:25:25Z
dc.date.issued2002
dc.description.abstractA series of hydrazide hydrazones and 1,3,4-oxadiazolines of 4-fluorobenzoic acid hydrazide were prepared and evaluated as potential antimicrobial agents and were tested for their antibacterial and antifungal activities against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. From these compounds, 4-fluorobenzoic acid[(5-nitro-2-furanyl)methylene]hydrazide (1a) showed equal activity with ceftriaxone against S. aureus. In addition, the MIC values of compounds 1c, 1d and 2a for the same strain were in the range of those reported for ceftriaxone according to NCCLS 1997.
dc.identifier.doi10.1016/s0014-827x(01)01192-2
dc.identifier.issn0014-827X
dc.identifier.pubmedPMID: 11902660
dc.identifier.urihttps://hdl.handle.net/11424/250261
dc.language.isoeng
dc.relation.ispartofFarmaco (Societa Chimica Italiana: 1989)
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBacteria
dc.subjectAnti-Bacterial Agents
dc.subjectHydrazones
dc.subjectMicrobial Sensitivity Tests
dc.subjectMolecular Structure
dc.subjectAnti-Infective Agents
dc.subjectCandida albicans
dc.subjectStructure-Activity Relationship
dc.titleSynthesis and antimicrobial activity of some new hydrazones of 4-fluorobenzoic acid hydrazide and 3-acetyl-2,5-disubstituted-1,3,4-oxadiazolines
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage174
oaire.citation.startPage171
oaire.citation.titleFarmaco (Societa Chimica Italiana: 1989)
oaire.citation.volume2

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