Publication: Multipl skleroz ve tiroid hastalıkları: İki olgu sunumu ve literatür bildirimi
Abstract
Multipl Skleroz (MS) tedavisinde kullanılan interferonların bilinen yan etkileri arasında tiroid hastalıkları yer alır. MS patogenezinde otoimmunitenin etkinliği bilinmektedir. MS'un tiroiditler gibi diğer otoimmun hastalıklarla birlikteliği izlenirken; MS tedavisinde kullanılan interferonlara bağlı olarak da tiroidit izlenebilir. Özellikle tedavinin ilk yıllarında izlenen tiroidit kliniği genellikle asemptomatik olup; tanı kontrol olarak bakılan laboratuvar tetkikleri ile konmaktadır. Bu yazıda, MS tedavisi için interferon kullanımı sırasında tiroid disfonksiyonu geliştiren iki olgu sunulmuştur.
Thyroid disease is a frequently seen side effect during interferon treatment of Multiple Sclerosis (MS). Autoimmunity is a well-known pathogenetic factor of MS. Tyhroiditis, and other autoimmune diseases may be seen together with MS. Also, thyroiditis may be caused by interferon treatment for MS. This side effect is especially, diagnosed in first year of the treatment. Patients with thyroid disease are usually asymptomatic and diagnosed by laboratory findings. In this report, we describe two MS patients with interferon treatment; one with subclinical hypothyroidism and one with thyrotoxicosis due to drug induced thyroiditis.
Thyroid disease is a frequently seen side effect during interferon treatment of Multiple Sclerosis (MS). Autoimmunity is a well-known pathogenetic factor of MS. Tyhroiditis, and other autoimmune diseases may be seen together with MS. Also, thyroiditis may be caused by interferon treatment for MS. This side effect is especially, diagnosed in first year of the treatment. Patients with thyroid disease are usually asymptomatic and diagnosed by laboratory findings. In this report, we describe two MS patients with interferon treatment; one with subclinical hypothyroidism and one with thyrotoxicosis due to drug induced thyroiditis.