Publication: Immunoexpression of HER family, neuregulin, MAPK and AKT in invasive ductal carcinomas of the breast
Abstract
Background:The purpose of this study was to investigate the frequency of expression of the erbB/HER family of growth factor receptors, their ligand neuregulinalpha (NRGalpha) and the most important pathways activated by HER receptors that are mitogen-activated protein kinase (MAPK) and serine/threonine kinase (AKT) in invasive ductal carcinomas of the breast, not otherwise specified (IDC-NOS).Methods:59 of the IDC-NOS of the breast were studied for ER, PR, EGFR, c-erbB-2, c-erbB-3, c-erbB-4, neuregulin Ab-3, phospho-AKT, and phospho-p44/42 map kinase using the streptavidin-biotin horseradish method.Results:Of the 59 tumours, 44 (75%) were ER+, 37 (63%) PR+, four (7%) EGFR+, seven (12%) c-erbB-2+, seven (12%) c-erbB-3+ and 14 (24%) c-erbB-4+alpha. Strong cytoplasmic and/or nuclear immunoexpression was revealed in 17 (29%) cases for NRGalpha, 13 (22%) cases for p-AKT, and nuclear immunoexpression with p-MAPK was found in 17 (29%) cases.Conclusion:The results suggest that high-grade breast carcinomas are not only associated with ER/PR- negativity, but seem to be activated by receptor tyrosine kinase growth factors.
Description
Keywords
Tıp, Sağlık Bilimleri, Temel Tıp Bilimleri, Biyoistatistik ve Tıp Bilişimi, Cerrahi Tıp Bilimleri, Patoloji, Sitoloji, Medicine, Health Sciences, Fundamental Medical Sciences, Biostatistics and Medical Informatics, Surgery Medicine Sciences, Pathology, Cytology, Klinik Tıp (MED), Yaşam Bilimleri (LIFE), Klinik Tıp, Biyoloji ve Biyokimya, CERRAHİ, TIBBİ BİLİŞİM, TIP, GENEL & DAHİLİ, PATOLOJİ, Clinical Medicine (MED), Life Sciences (LIFE), CLINICAL MEDICINE, BIOLOGY & BIOCHEMISTRY, SURGERY, MEDICAL INFORMATICS, MEDICINE, GENERAL & INTERNAL, PATHOLOGY, Histoloji, Patoloji ve Adli Tıp, Aile Sağlığı, Temel Bilgi ve Beceriler, Cerrahi, Tıbbi Bilişim, Genel Sağlık Meslekleri, Patofizyoloji, Dahiliye, Değerlendirme ve Teşhis, Tıp (çeşitli), Genel Tıp, Histology, Pathology and Forensic Medicine, Family Practice, Fundamentals and Skills, Surgery, Health Informatics, General Health Professions, Pathophysiology, Internal Medicine, Assessment and Diagnosis, Medicine (miscellaneous), General Medicine
Citation
Kaya H., Erbarut İ., Özkan N., Bekiroğlu G. N., Şen S., Abacıoğlu U., "Immunoexpression of HER family, neuregulin, MAPK and AKT in invasive ductal carcinomas of the breast", EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, cilt.29, sa.4, ss.350-356, 2008