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Synthesis and preliminary anticancer activity of new 1,4-dihydro-3-(3-hydroxy-2-naphthyl)-4-substituted-5H-1,2,4-triazoline-5-thiones

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dc.contributor.authorsDuran, A.; Dogan, H. N.; Rollas, Sevim
dc.date.accessioned2022-03-15T11:22:29Z
dc.date.accessioned2026-01-11T17:15:07Z
dc.date.available2022-03-15T11:22:29Z
dc.date.issued2002
dc.description.abstract1,4-Dihydro-3-(3-hydroxy-2-naphthyl)-4-substituted-5H-L2,4-triazolinc-5-thiones were synthesized. The structures of original eight compounds were confirmed by elemental analysis, 1H NMR and mass spectral methods. One of the compounds (3a) was tested in vitro for its anticancer activity against 52 human tumor cell lines.
dc.identifier.doi10.1016/s0014-827x(02)01248-x
dc.identifier.issn0014-827X
dc.identifier.pubmedPMID: 12164214
dc.identifier.urihttps://hdl.handle.net/11424/249773
dc.language.isoeng
dc.relation.ispartofFarmaco (Societa Chimica Italiana: 1989)
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHumans
dc.subjectAntineoplastic Agents
dc.subjectTriazoles
dc.subjectTumor Cells, Cultured
dc.subjectDose-Response Relationship, Drug
dc.subjectMolecular Structure
dc.subjectCell Division
dc.subjectThiones
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectDrug Screening Assays, Antitumor
dc.titleSynthesis and preliminary anticancer activity of new 1,4-dihydro-3-(3-hydroxy-2-naphthyl)-4-substituted-5H-1,2,4-triazoline-5-thiones
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage564
oaire.citation.startPage559
oaire.citation.titleFarmaco (Societa Chimica Italiana: 1989)
oaire.citation.volume7

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