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ANTINOCICEPTIVE EFFECT OF D-ASPARTIC ACID IN MICE

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dc.contributor.authorsONAT, F; TOKER, F; ASLAN, N; OKTAY, S; BERKMAN, K
dc.date.accessioned2022-03-12T16:56:11Z
dc.date.accessioned2026-01-11T08:54:20Z
dc.date.available2022-03-12T16:56:11Z
dc.date.issued1995
dc.description.abstractThe effects of D- and L-aspartic acids on the nociceptive tail flick reflex in mice were investigated. D-Aspartic acid (115-230 mg/kg, IF) was found to increase tail flick latency significantly. Naloxone (0.1 mg/kg) abolished the analgesic effect of D-aspartic acid (115 mg/kg). Morphine and D-aspartic acid, when combined at their nonanalgesic doses, led to significant analgesia. It may be concluded that the opioid system is involved in the antinociceptive effect of D-aspartic acid. Both morphine and D-aspartic acid were previously reported to inhibit L-aspartic acid production via blockade of L-asparaginase. L-Aspartic acid, which was ineffective alone, significantly inhibited the antinociceptive effects of both D-aspartic acid and morphine.
dc.identifier.doi10.1016/0091-3057(95)00016-P
dc.identifier.issn0091-3057
dc.identifier.pubmed7675849
dc.identifier.urihttps://hdl.handle.net/11424/226689
dc.identifier.wosWOS:A1995RF37700024
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofPHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectASPARTIC ACID
dc.subjectANALGESIA
dc.subjectMORPHINE
dc.subjectNALOXONE
dc.subjectRAT SPINAL-CORD
dc.subjectAMINO-ACIDS
dc.subjectDORSAL HORN
dc.subjectMORPHINE-DEPENDENCE
dc.subjectKETAMINE ANALGESIA
dc.subjectNMDA RECEPTORS
dc.subjectNALOXONE
dc.subjectGLUTAMATE
dc.subjectNEURONS
dc.subjectNEUROTRANSMISSION
dc.titleANTINOCICEPTIVE EFFECT OF D-ASPARTIC ACID IN MICE
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage719
oaire.citation.issue4
oaire.citation.startPage715
oaire.citation.titlePHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
oaire.citation.volume51

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