Publication:
Evaluation of toxic effects of dapagliflozin on reproductive system in diabetic rats

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsKaraca B. U. , Boran T., Koroglu A. K. , ERCAN F., Ozhan G.
dc.date.accessioned2022-12-02T12:59:42Z
dc.date.accessioned2026-01-11T10:30:16Z
dc.date.available2022-12-02T12:59:42Z
dc.date.issued2022-01-01
dc.description.abstractBackground/aim: Dapagliflozin (DAPA), sodium-glucose cotransporter 2 (SGLT2) inhibitor, is an insulin-independent antidiabetic drug used to control hyperglycaemia by promoting glucose excretion from the kidney. Its adverse effects include orthostatic hypotension, dehydration and urinary tract and genital infections caused by glycosuria. DAPA is subjected to constant additional monitoring, as drug-related adverse reactions are frequently updated in line with the results of case studies, clinical trials and in vivo studies. Some antidiabetic drugs have shown potential harmful effects on the male reproductive system; however, the effects of DAPA have not been sufficiently studied in this capacity. Aiming to fill this gap in the literature, the present work investigates the toxic effects of DAPA on the male reproductive system.
dc.identifier.citationKaraca B. U. , Boran T., Koroglu A. K. , ERCAN F., Ozhan G., "Evaluation of toxic effects of dapagliflozin on reproductive system in diabetic rats", TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.52, sa.4, ss.1362-1370, 2022
dc.identifier.doi10.55730/1300-0144.5443
dc.identifier.endpage1370
dc.identifier.issn1300-0144
dc.identifier.issue4
dc.identifier.startpage1362
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/a23fb653-a56f-46ce-83da-c4190664b8d3/file
dc.identifier.urihttps://hdl.handle.net/11424/283510
dc.identifier.volume52
dc.language.isoeng
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectGenel Sağlık Meslekleri
dc.subjectPatofizyoloji
dc.subjectTemel Bilgi ve Beceriler
dc.subjectDeğerlendirme ve Teşhis
dc.subjectDahiliye
dc.subjectAile Sağlığı
dc.subjectTıp (çeşitli)
dc.subjectGenel Tıp
dc.subjectGeneral Health Professions
dc.subjectPathophysiology
dc.subjectFundamentals and Skills
dc.subjectAssessment and Diagnosis
dc.subjectInternal Medicine
dc.subjectFamily Practice
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Medicine
dc.subjectType-2 diabetes
dc.subjectdapagliflozin
dc.subjectmale reproductive system
dc.subjectoxidative damage
dc.subjectGLUCOSE COTRANSPORTER 2
dc.subjectOXIDATIVE STRESS
dc.subjectMALE-FERTILITY
dc.subjectCHRONIC SAFETY
dc.subjectINHIBITOR
dc.subjectMELLITUS
dc.subjectPARAMETERS
dc.subjectMORPHOLOGY
dc.subjectAPOPTOSIS
dc.subjectSPERM
dc.subjectType-2 diabetes
dc.subjectdapagliflozin
dc.subjectmale reproductive system
dc.subjectoxidative damage
dc.titleEvaluation of toxic effects of dapagliflozin on reproductive system in diabetic rats
dc.typearticle
dspace.entity.typePublication

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