Publication:
Hypotension under antihypertensive treatment and incident hospitalizations of nursing home residents

dc.contributor.authorTUFAN ÇİNÇİN, ASLI
dc.contributor.authorsBahat G., Ilhan B., TUFAN ÇİNÇİN A., Kilic C., Karan M. A., Petrovic M.
dc.date.accessioned2023-07-06T13:09:48Z
dc.date.accessioned2026-01-11T06:01:59Z
dc.date.available2023-07-06T13:09:48Z
dc.date.issued2022-06-01
dc.description.abstractBackground and Objective Hypertension is the most prevalent chronic disease in older adults. Antihypertensive drug use increases with aging. In some studies, hypotension developing under antihypertensive medication use has been indicated as a potential risk factor for morbidity and mortality in older adults. Our objective was to assess the relationship between hypotension under antihypertensive treatment and incident hospitalization of nursing home residents. Methods We detailed blood pressure measurements of the previous 1-year period that were noted regularly at 2-week intervals and studied their mean values. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) thresholds to define low SBP (<= 110 mm Hg) and DBP (<= 65 mm Hg) were derived from our previous study. We noted demographics, number of co-morbidities and regular medications, mobility status, and nutritional assessment via the Mini Nutritional Assessment Short Form. Results We included 253 participants (66% male, mean age 75.7 +/- 8.7 years). The prevalence of low SBP (<= 110 mmHg) and low DBP (<= 65 mmHg) was 34.8% and 15.8%, respectively. Among residents, 4% were bedridden, 15.8% wheelchair bound, 14.5% needing assistance for reduced mobility, and 62.7% were ambulatory. At a median of 15 months of follow-up, hospitalization incidence from any cause was 50.8% (n = 134). Incident hospitalization was more common in the group that had low DBP (odds ratio = 3.06; 95% confidence interval 1.02-9.15; p = 0.04) after adjusting for age, number of comorbidities and medications, mobility status, and nutritional status. Low SBP was not associated with hospitalization. Conclusions The low DBP (<= 65 mm Hg) during the previous year was associated with incident hospitalization of nursing home residents after adjustment for several factors. These findings indicate that lower DBP may be a causative factor for incident hospitalization. We need further studies to explore whether a correction of diastolic hypotension may decrease the hospitalization risk in this vulnerable population.
dc.identifier.citationBahat G., Ilhan B., TUFAN ÇİNÇİN A., Kilic C., Karan M. A., Petrovic M., "Hypotension Under Antihypertensive Treatment and Incident Hospitalizations of Nursing Home Residents", DRUGS & AGING, cilt.39, sa.6, ss.477-484, 2022
dc.identifier.doi10.1007/s40266-022-00951-0
dc.identifier.endpage484
dc.identifier.issn1170-229X
dc.identifier.issue6
dc.identifier.startpage477
dc.identifier.urihttps://hdl.handle.net/11424/290891
dc.identifier.volume39
dc.language.isoeng
dc.relation.ispartofDRUGS & AGING
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectTemel Eczacılık Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectGeriatri
dc.subjectEczacılık
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectBasic Pharmaceutics Sciences
dc.subjectHealth Sciences
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectGeriatrics
dc.subjectPharmacology and Therapeutics
dc.subjectLife Sciences
dc.subjectNatural Sciences
dc.subjectGERİATRİ ve GERONTOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectGERIATRICS & GERONTOLOGY
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectLife Sciences (LIFE)
dc.subjectFarmakoloji
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)
dc.subjectFarmakoloji (tıbbi)
dc.subjectGeriatri ve Gerontoloji
dc.subjectİlaç Rehberleri
dc.subjectPharmacology
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectPharmacology (medical)
dc.subjectGeriatrics and Gerontology
dc.subjectPharmacy
dc.subjectDrug Guides
dc.titleHypotension under antihypertensive treatment and incident hospitalizations of nursing home residents
dc.typearticle
dspace.entity.typePublication

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