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Stable hemiaminals from axially chiral pyridine compounds

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dc.contributor.authorERDEM, SAFİYE
dc.contributor.authorsTuncel S. T., Demir I., ERDEM S., Dogan I.
dc.date.accessioned2023-02-20T10:43:04Z
dc.date.accessioned2026-01-10T21:14:37Z
dc.date.available2023-02-20T10:43:04Z
dc.date.issued2023-01-01
dc.description.abstract© 2023 Wiley Periodicals LLC.In this study, we have synthesized a series of 3-(pyridin-2-yl)-2-(pyridin-2-ylimino)thiazolidin-4-ol derivatives regioselectively from 2-iminothiazolidin-4-ones using LiAlH4 at room temperature. Due to the presence of the restricted rotation around the N3-Caryl single bond, the formation of M/P isomers was observed. The OH group of the hemiaminal was found to orient itself on the same side with pyridyl nitrogen during this restricted rotation to form an intramolecular hydrogen bond, which was demonstrated by the computational DFT study. This orientation presumably inhibited the occurrence of dehydration and stabilized the molecule.
dc.identifier.citationTuncel S. T., Demir I., ERDEM S., Dogan I., "Stable hemiaminals from axially chiral pyridine compounds", Chirality, 2023
dc.identifier.doi10.1002/chir.23545
dc.identifier.endpage11
dc.identifier.issn0899-0042
dc.identifier.startpage1
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85147584885&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/286590
dc.language.isoeng
dc.relation.ispartofChirality
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTemel Eczacılık Bilimleri
dc.subjectEczacılık
dc.subjectKimya Mühendisliği ve Teknolojisi
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectKimya
dc.subjectAnalitik Kimya
dc.subjectBiyokimya
dc.subjectBiyoinorganik Kimya
dc.subjectFizikokimya
dc.subjectSpektroskopi
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectBasic Pharmaceutics Sciences
dc.subjectPharmacology and Therapeutics
dc.subjectChemical Engineering and Technology
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectChemistry
dc.subjectAnalytical Chemistry
dc.subjectBiochemistry
dc.subjectBioinorganic Chemistry
dc.subjectPhysical Chemistry
dc.subjectSpectroscopy
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectTemel Bilimler (SCI)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMühendislik
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectMÜHENDİSLİK, KİMYASAL
dc.subjectKİMYA, ANALİTİK
dc.subjectSPEKTROSKOPİ
dc.subjectKİMYA, ORGANİK
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectNatural Sciences (SCI)
dc.subjectLife Sciences (LIFE)
dc.subjectENGINEERING
dc.subjectCHEMISTRY
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectENGINEERING, CHEMICAL
dc.subjectCHEMISTRY, ANALYTICAL
dc.subjectSPECTROSCOPY
dc.subjectCHEMISTRY, ORGANIC
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectFizik Bilimleri
dc.subjectKataliz
dc.subjectFarmakoloji
dc.subjectİlaç Keşfi
dc.subjectOrganik Kimya
dc.subjectPhysical Sciences
dc.subjectCatalysis
dc.subjectPharmacology
dc.subjectDrug Discovery
dc.subjectOrganic Chemistry
dc.subject2-iminothiazolidin-4-ol
dc.subjectaxially chiral hemiaminal
dc.subjectintramolecular hydrogen bonding
dc.subjectpyridine compounds
dc.subjectstable hemiaminal
dc.subject2-iminothiazolidin-4-ol
dc.subjectaxially chiral hemiaminal
dc.subjectintramolecular hydrogen bonding
dc.subjectpyridine compounds
dc.subjectstable hemiami
dc.titleStable hemiaminals from axially chiral pyridine compounds
dc.typearticle
dspace.entity.typePublication

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