Publication: Aprotinin improves Ca2+ - Mg2+ / ATPase levels in ischemia-reperfusion injury
| dc.contributor.authors | Isbir C.S., Doǧan R., Demircin M., Paşaoǧlu I. | |
| dc.date.accessioned | 2022-03-28T14:51:30Z | |
| dc.date.accessioned | 2026-01-11T15:26:31Z | |
| dc.date.available | 2022-03-28T14:51:30Z | |
| dc.date.issued | 2002 | |
| dc.description.abstract | Objective: The aim of this study is to determine the effect of aprotinin, on calcium activated and magnesium dependent adenosine 5′ triphosphatase (Ca2+-Mg2+/ATP ase) levels. Methods: Twenty patients who had elective coronary artery bypass grafting (CABG) were randomly divided into two groups (n= 10, in each). Group A patients received full dose aprotinin (20 000 IU/kg as pretreatment followed by 7500 IU/kg for 6 hours) and Group B patients received normal saline as control group. Erythrocyte membrane Ca2+-Mg2+/ATP ase levels were measured. Results: Ca2+-Mg2+ /ATPase levels were protected in aprotinin group, 807.60±32.62 vs 634.28±22.91 (p<0.05) at post-operative 24th hour. (p<0.05). Conclusion: Aprotinin protected the erythocyte membrane Ca2+-Mg2+ ATP/ase from oxidant stress thus it might affect the cell membrane stabilization. | |
| dc.identifier.issn | 10191941 | |
| dc.identifier.uri | https://hdl.handle.net/11424/255690 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Marmara Medical Journal | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | Aprotinin | |
| dc.subject | Ca2+-Mg2+/ATPase | |
| dc.subject | Ischemia-Reperfusion injury | |
| dc.title | Aprotinin improves Ca2+ - Mg2+ / ATPase levels in ischemia-reperfusion injury | |
| dc.type | article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 26 | |
| oaire.citation.issue | 1 | |
| oaire.citation.startPage | 23 | |
| oaire.citation.title | Marmara Medical Journal | |
| oaire.citation.volume | 15 |