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DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma

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dc.contributor.authorBARIŞ, SAFA
dc.contributor.authorsOzdemir, Nihal; Celkan, Tiraje; Baris, Safa; Batar, Bahadir; Guven, Mehmet
dc.date.accessioned2022-03-12T18:06:29Z
dc.date.accessioned2026-01-11T06:10:41Z
dc.date.available2022-03-12T18:06:29Z
dc.date.issued2012
dc.description.abstractThe aim of the study is to investigate association between DNA repair gene XPD and XRCC1 polymorphisms and febrile neutropenia (FN) and mucositis. The study population consisted of 29 children with Burkitt lymphoma and 61 children with acute lymphoblastic leukemia. Analysis revealed that XRCC1194Trp allele showed a protective effect against longer FN and mucositis. There was also statistically increased risk for severe mucositis in patients with XRCC1Arg399Gln polymorphism. There are no studies that have examined this relationship before. Further studies with larger cohorts are needed to clarify the association. (C) 2011 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.leukres.2011.10.012
dc.identifier.eissn1873-5835
dc.identifier.issn0145-2126
dc.identifier.pubmed22047709
dc.identifier.urihttps://hdl.handle.net/11424/230912
dc.identifier.wosWOS:000302117200016
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofLEUKEMIA RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFebrile neutropenia
dc.subjectXRCC1 and XPD polymorphisms
dc.subjectMucositis
dc.subjectCANCER
dc.subjectASSOCIATION
dc.subjectIMMUNODEFICIENCY
dc.subjectSUSCEPTIBILITY
dc.subjectCHEMOTHERAPY
dc.subjectRADIOTHERAPY
dc.subjectMORTALITY
dc.subjectTOXICITY
dc.subjectCAPACITY
dc.subjectERCC2
dc.titleDNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma
dc.typearticle
dspace.entity.typePublication
oaire.citation.endPage569
oaire.citation.issue5
oaire.citation.startPage565
oaire.citation.titleLEUKEMIA RESEARCH
oaire.citation.volume36

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