Person: YÜCEL, SELÇUK
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YÜCEL
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SELÇUK
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Publication Metadata only Accuracy of transrectal ultrasound guided prostate biopsy: Histopathological correlation to matched prostatectomy specimens(BLACKWELL PUBLISHING ASIA, 2002) ÇAM, HAYDAR KAMİL; Cam, K; Yucel, S; Turkeri, L; Akdas, ABackground: The Gleason grading system is currently the world's most commonly used histological system for prostate cancer. It provides significant information about the prognosis. Therefore, Gleason score is accepted as an important factor in therapeutic decision-making for prostate cancer. This retrospective study assessed the correlation of transrectal ultrasound (TRUS) guided biopsy and radical prostatectomy specimens in terms of Gleason scores. Methods: We reviewed the records of 103 patients who underwent radical prostatectomy due to clinically localized prostate cancer. The Gleason scores of the TRUS biopsies were compared with the respective Gleason scores of surgical specimen. Results: In 28.7% of cases, the TRUS biopsy score was the same as that of the radical prostatectomy specimen. The most significant discordance was the upgrading of well-differentiated tumors after surgery in 71.7% of cases. However, in 81.8% of cases with high Gleason score on TRUS, biopsy was correlated with poorly differentiated tumor after surgery. Conclusions: Well-differentiated tumors on TRUS biopsy did not correlate with the grades of final pathology in the majority of cases; however, a high Gleason score on TRUS biopsy usually indicated a poorly differentiated tumor on prostatectomy specimen. Therefore, the treatment algorithms for particularly well-differentiated tumors should not be deduced from biopsy histology alone.Publication Open Access Consistency of uroflowmetry analysis in children among observers(2023-01-01) ŞEKERCİ, ÇAĞRI AKIN; TANIDIR, YILÖREN; TARCAN, TUFAN; YÜCEL, SELÇUK; ŞEKERCİ Ç. A., TANIDIR Y., TARCAN T., YÜCEL S.© 2023 Wiley Periodicals LLC.Aim: The aim of the study is to compare the intra- and inter-observer interpretations of the same uroflowmetry study at two different times. Materials and Methods: Two-hundred children with a voided volume of 50% above the expected bladder capacity were included. All traces were asked to be evaluated by 11 observers two times in a time span of 1 month. These observers consist of pediatric urologists (n = 2), pediatric urology fellows (n = 2), urology residents (n = 5), and certified urodynamics nurses (n = 2). Each uroflowmetry was asked to be assessed for three domains: voided volume (VV), detrusor sphincter dyssynergia (DSD), and flow curve pattern (FCP). Results: Of the 200 patients with a median age of 10 (4–18) years, 128 (64%) were girls and 72 (36%) boys. The maximum flow rate and the median voided volume were found to be 20 (4–61) mL/s and 232 (116–781) mL. The Fleiss\" kappa coefficient of VV, DSD, and FCP in the first assessment was 0.510, 0.501, and 0.346. In the second assessment, κ values were 0.530, 0.422, and 0.373. The best-agreed findings were similar at both times. These were found to be low VV (0.602 and 0.626) and intermittent pattern (0.500 and 0.553). Interpreters were found to have a statistically significant difference in agreement with their own interpretation at different times. Conclusion: Both inter- and intra-observer reliability of the agreement point out the problem in the standardization of uroflowmetry. Inter- and intra-observer reliability of uroflowmetry interpretation can be increased by defining precise numbers and numerical algorithms.Publication Metadata only The comparison of anxiety levels in children who underwent invasive or non-invasive urodynamic studies(2022-05-13) ŞEKERCİ, ÇAĞRI AKIN; TARCAN, TUFAN; YÜCEL, SELÇUK; TANIDIR, YILÖREN; Sekerci C. A., Can Ozkan O., Tanidir Y., Tarcan T., Yucel S.INTRODUCTION AND OBJECTIVE: Urodynamic studies play an important role in the evaluation of children with lower urinary tract dysfunction. In this study, we aimed to examine the effects of invasive and non-invasive urodynamic studies on the anxiety levels of children with the help of an anxiety scale. METHODS: Children aged 8-17 years who were scheduled for uroflowmetry (UF) or filling cystometry (FC) and who agreed to fill out an anxiety scale were included in the study. It was the first UF or FC of all children. “The Screen for Child Anxiety Related Disorders (SCARED)” form consisting of 41 questions was used in the evaluation. All children included in the study filled the form themselves. The SCARED results of children who underwent UF and FC were compared. RESULTS: A total of 56 children with a mean age of 10.85þ/- 2.98 years were included in the study. 31 (55.4%) of the children were females and 25 (44.6%) were males. The number of children who had UF was 26 (46.4%; 8.5 (8-14) years), and 30 (53.6%; 11.5 (8-17) years) had FC. The total SCARED scores of the children who underwent UF and FC were 26.5 (5-75) and 27 (2-57), respectively, and there was no statistical difference (p[0.980) (Table 1). A significant difference was found only in "Separation Anxiety Disorder" among sub-score evaluations (p[0.049) (Table 1). In children who underwent filling cystometry, there was no statistical difference in the total SCARED score between those who did and did not do clean intermittent catheterization (28 (3-41); 27 (2-57), respectively) (p[0.860). CONCLUSIONS: The SCARED scores above 25 indicate an anxiety disorder, and interestingly, in this study, both the invasive and noninvasive urodynamic study groups scored over 25. We consider that non-invasive urodynamic tests may cause stress on children as much as invasive ones.Publication Metadata only Durability of a single successful endoscopic polytetrafluoroethylene injection for primary vesicoureteral reflux: 14-year followup results(ELSEVIER SCIENCE INC, 2007) ŞİMŞEK, FERRUH; Yucel, Selcuk; Tarcan, Tufan; Simsek, FerruhPurpose: We reviewed our 14-year experience with successful single endoscopic subureteral polytetrafluoroethylene injection for the treatment of primary vesicoureteral reflux in children. Materials and Methods: We retrospectively reviewed the charts of 42 patients with primary vesicoureteral reflux who were treated with a single successful subureteral polytetrafluoroethylene injection between 1989 and 1993 and followed with routine 1, 3 and 10-year voiding cystourethrography. Results: The study included 30 girls and 12 boys 2 to 14 years old (median age 6 years). Four patients were lost to followup. Of the 38 remaining patients 28 had unilateral and 10 had bilateral primary vesicoureteral reflux. Endoscopic treatment with subureteral. polytetrafluoroethylene injection was performed in 48 ureters. Followup ranged from 10 to 14 years (mean 12.5 +/- 2.1). Voiding cystourethrography in 38 patients and 48 ureters revealed that 35 ureters (73%) remained free of reflux, whereas reflux recurred in 13 (27%) at a median of 2 years. Of these 13 ureters recurring reflux was grade I to II in 5 and grade III to V in 8. Reflux recurred in 11 of 24 ureters with grade IV to V reflux. Of the 13 recurrences 10 presented as febrile urinary tract infections and only 3 grade I recurrences were detected on voiding cystourethrography alone. No untoward effects were seen in any of these patients with injection of polytetrafluoroethylene. Conclusions: Long-term followup may be warranted after a single successful endoscopic injection for vesicoureteral reflux, particularly high grade reflux. However, followup voiding cystourethrography is unnecessary in patients presenting with febrile urinary tract infection.Publication Metadata only Predictive factors of full response to desmopressin treatment in children with primary monosymptomatic enuresis nocturna(2023-02-01) ÖZGÜR, GÜNAL; TANIDIR, YILÖREN; TARCAN, TUFAN; YÜCEL, SELÇUK; Ozgur G., Sekerci C. A., TANIDIR Y., Tarcan T., YÜCEL S.Publication Open Access Diagnosis of Testicular Torsion and Differentiation From Other Pathologies Using Near-Infrared Spectroscopy(2023-01-01) ŞEKERCİ, ÇAĞRI AKIN; YÜCEL, SELÇUK; ÇAM, HAYDAR KAMİL; Ali Üncü Y., ŞEKERCİ Ç. A., YÜCEL S., Sircan-Kucuksayan A., ÇAM H. K., Savaş M., Yıldırım A., Ağras K., Baykara M., CANPOLAT M.© 2023 Elsevier Inc.Objective: To develop a near-infrared (NIR) spectroscopy device to diagnose testicular torsion with high sensitivity and specificity. Specifically, we aim to investigate the differentiation between testicular torsion from other pathologies such as orchidoepididymitis, varicocele, and hydrocele. Methods: Two LEDs with wavelengths of 660 nm and 940 nm were used as light sources in the device. Each wavelength was sent to the testicle successively, and a photodiode detected back-reflected diffuse light. The ratio of the light intensities of 660 nm and 940 nm was used as a diagnostic parameter. A multi-center clinical trial was performed in 5 different hospitals. Results: In total, 62 patients in urology clinics with acute testicular pain have been recruited for the study. The developed NIR spectroscopy correctly defined all 8 testicular torsion cases. Besides, 3 orchidoepididymitis, 1 varicocele, and 3 hydrocele cases were correctly distinguished from testicular torsion. Only 1 hydrocele case was misdiagnosed as torsion. The range of the ratio was between 0.14 and 1.16 overall measurements. The ratio varied between 0.14 and 0.3 for the testicle with torsion. The ratio was between 0.49 and 1.16 for the normal testicle and testicle with other pathologies mentioned above. Conclusion: We have chosen the threshold ratio of 0.4 to differentiate between the normal and torsion testis and diagnosed all the torsion cases among all normal and other pathologies. The developed optical device to diagnose testicular torsion is inexpensive, user-friendly, and works based on objective criteria with high sensitivity and specificity in real time.Publication Open Access The association of urinary BDNF, ATP, and MMP-2 with bladder compliance in children with myelodysplasia(2023-01-01) ŞEKERCİ, ÇAĞRI AKIN; KÜTÜKOĞLU, MEHMET UMUT; YÜCEL, SELÇUK; TARCAN, TUFAN; ŞEKERCİ Ç. A., KÜTÜKOĞLU M. U., Basok B. I., Fidan M., ÇAM S., YÜCEL S., TARCAN T.Aim: The purpose of our study was to evaluate the relationship of urinary brain-derived neurotrophic factor (BDNF), adenosine triphosphate (ATP), matrix metallopreteinase-2 (MMP-2) with urodynamic findings and upper urinary tract deterioration (UUTD) in children with myelodysplasia. Materials and Methods: Children with myelodysplasia evaluated in outpatient clinic between 2022 and 2023 were included. All patients underwent urinary ultrasonography, voiding cystourethrography, urodynamics, and DMSA scintigraphy. Urine samples were collected before urodynamics. Control urine was collected from 10 healthy children. Urinary biomarker values of patients and controls were compared, and subgroup analysis was performed. Results: The median age of 40 children (26 girls) included in the study was 108 (8–216) months, and the control group (six girls) was 120 (60–154) (p = 0.981). Urinary BDNF, MMP-2, and ATP were found to be significantly higher in children with myelodysplasia compared to the control (p = 0.007, p = 0.027, p = 0.014, respectively). The three biomarker values were similar in children with bladder compliance below or above 10 cmH2O/mL (p = 0.750, p = 0.844, p = 0.575). No difference was found in terms of UUTD in all three biomarkers (p = 0.387, p = 0.892, p = 0.705). A negative correlation was found between urinary ATP and compliance (p < 0.05). Conclusion: In this study, all three biomarkers were found to be higher in children with myelodysplasia than in controls. There was a negative correlation between urinary ATP and compliance. Urinary biomarkers may contribute the follow-up of children with neurogenic lower urinary tract deterioration in future with their noninvasive features. However, the lack of standardization and the inability to reliably predict risky groups are important shortcomings of urinary biomarkers.Publication Metadata only Obstrüktif üropati(Güneş Tıp Kitabevi, 2023-11-01) ŞEKERCİ, ÇAĞRI AKIN; YÜCEL, SELÇUK; Şekerci Ç. A., Yücel S.Publication Open Access Primer monosemptomatik enürezis nokturnası olan çocuklarda desmopressin tedavisine tam yanıtın prediktif faktörleri(2023-10-04) ŞEKERCİ, ÇAĞRI AKIN; TARCAN, TUFAN; YÜCEL, SELÇUK; Özgür G., Şekerci Ç. A., Tanıdır Y., Tarcan T., Yücel S.AMAÇ: Primer monosemptomatik enürezis nokturna (PMEN), pediatrik ürolojide sık görülen bir problemdir ve medikal tedavide ilk tercih desmopressindir. Bu çalışmada, desmopressine tam yanıt alınan PMEN'li çocuklarda prediktif faktörleri ve desmopressinin idrar elektrolit düzeyleri (sodyum, potasyum ve kalsiyum) üzerindeki etkisini değerlendirmeyi amaçladık. MATERYAL-METOD: Çalışmaya çocuk ürolojisi polikliniğine başvurup PMEN tanısı alan ve desmopressin tedavisi başlanan çocuklar dahil edildi. Gündüz semptomları olan veya sekonder enürezisi bulunan çocuklar çalışmaya alınmadı. Hastalar fizik muayene, idrar tahlili, semptom skoru ve işeme günlüğü ile değerlendirildi. Tüm hastalara 120 mcg desmopressin başlandı. Hastalardan tedavi öncesinde, tedavi sonrası ise 1. ve 3. aylarda elektrolit değerlendirmesi için 24 saatlik idrar toplandı. Üçüncü aydaki semptomlarına göre tedaviye tam yanıt veren grup ve diğer (tedaviye dirençli veya kısmi yanıtlı) grup olarak hastalar ikiye ayrıldı. Hastaların tedavi öncesi ve tedavi sonrası elektrolit değerleri karşılaştırıldı ve tam yanıtlı grupta yanıtı öngörebilecek olası prediktif faktörler değerlendirildi. BULGULAR: Çalışmaya 34 çocuk (23 erkek, 11 kız) dahil edildi. Ortanca yaş 8 (5-15) idi. Tedavi öncesi ve sonrasındaki (1. ve 3. ay) idrar dansitesi, 24 saatlik idrar sodyum, potasyum ve kalsiyum değerleri arasında fark yoktu (p=0,432, 0,822, 0,970, 0,970, sırasıyla). Cinsiyet, bir aydaki ıslak gece sayısı ve bir gecede olan idrar kaçırma sayısı desmopressine tam yanıtı öngören faktörler olarak bulundu (p=0,015, 0,022, p=0,001, sırasıyla) (Tablo 1). Yaşın, aile öyküsünün, işeme günlüğündeki mesane kapasitesi/beklenen mesane kapasitesinin ve tedavi öncesi idrar sodyum seviyesinin tam yanıtı öngörme üzerinde etkisinin olmadığı gösterildi (p=0,230, p=0,547, p=0,763, p=0.060, sırasıyla) (Tablo 1). SONUÇ: PMEN'li çocuklarda erkek cinsiyet olması, bir ayda çok sayıda ıslak gece olması ve bir gecede çoklu idrar kaçırma olması desmopressin tedavisine tam yanıt alınmasında olumsuz faktörler olarak bulundu.Publication Metadata only Alt üriner sistem disfonksiyonu olan çocuklarda üç günlük işeme günlüğündeki işeme hacimleri ve sıklıkları farklı mıdır(2023-10-25) ŞEKERCİ, ÇAĞRI AKIN; YÜCEL, SELÇUK; TARCAN, TUFAN; Ergün R., Şekerci Ç. A., Çetin M., Sahak M. Y., Yücel S., Tarcan T.
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