Person: AYAZ SEYHAN, SERAP
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AYAZ SEYHAN
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SERAP
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Publication Metadata only Preparation and characterization of electrospun polylactic acid/sodium alginate/orange oyster shell composite nanofiber for biomedical application(SPRINGER, 2020) BİLĞİÇ ALKAYA, DİLEK; Cesur, Sumeyye; Oktar, Faik Nuzhet; Ekren, Nazmi; Kilic, Osman; Alkaya, Dilek Bilgic; Seyhan, Serap Ayaz; Ege, Zeynep Ruya; Lin, Chi-Chang; Erdem, Serap; Erdemir, Gokce; Gunduz, OguzhanBone tissue engineering has begun to draw attention in recent years. The interactive combination of biomaterials and cells is part of bone tissue engineering. Sodium alginate (SA) is a biologically compatible, degradable, non-toxic natural polymer accepted by the human body and is widely used in the field of tissue engineering. Polylactic acid (PLA) is another type of biodegradable thermoplastic polyester derived from renewable sources which are used in bone tissue engineering and biomedical owing to its biocompatibility and biodegradability. Hydroxyapatite (HA) and tricalcium phosphate (TCP) derived from natural sources such as marine species and bovine bone are biocompatible and non-toxic biomaterials which are used to reconstruct many parts of the skeleton. In this study, PLA, SA with different compositions, and nanofibers obtained by adding orange spiny oyster shell powders (Spondylus barbatus) to them by using electrospining technique. Cell culture study, scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and physical analysis such as density, electrical conductivity, surface tension, viscosity measurement, and tensile strength measurement tests were carried out after the production process. Produced nanofibers showed smooth and beadless surface. The average diameters and distributions decreased with the addition of optimum PLA and TCP amount. The tensile strength of nanofibers was enhanced with the additional SA and TCP. The produced nanofibers are compatible with human bone tissue, which are not cytotoxic, and in addition, a high cell efficiency of SaOS-2 cells on the nanofibers was observed with SEM images.Publication Metadata only Fabrication and characterization of pla/sa/ha composite nanofiber by electrospinning for bone tissue engineering applications(2018-07-18) CESUR, SÜMEYYE; EKREN, NAZMİ; KILIÇ, OSMAN; OKTAR, FAİK NÜZHET; BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; GÜNDÜZ, OĞUZHAN; Cesur S., Ekren N., Kılıç O., Oktar F. N., Bilğiç Alkaya D., Ayaz Seyhan S., Ege Z. R., Gündüz O.Publication Metadata only Loading of tuberculosis drugs to nanofiber structures, fiber optimization(2019-06-28) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Onurlu H. İ., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O.uberculosis is a disease caused by a bacillus called mycobacterium tuberculosis which can be seen in other organs, especially in the lungs. Tuberculosis is an infectious, infectious, inflammatory, acute or chronic-trending bacterial infection. Since the treatment is insufficient with a single drug and the bacilli are resistant to this antibiotic, various antituberculosis drugs are used side by side during the treatment. Side-by-side use of the drugs breaks the resistance of the bacteria but creates a lot of side effects for the patient. We aim to reduce the existing side effects by loading the active agents of rifampicin, isoniazid, pyrazinamide and ethambutol, which are used as antituberculosis drugs, to a biodegradable nanofib. Primarily, PCL polymer material was dissolved in DMF: THF (v / v). After preparing PCL solution in 3%, 6%, 9%, 12% and 15% concentrations, optimization studies were performed by using electrospin device at various voltages. The SEM images of the obtained PCL fibers were examined and drug loading was performed at the suitable PCL concentration. In the planned study, FTIR images of the fibers loaded with the drug will be examined and controlled drug oscillations will be provided at the stomach and intestinal pH as an in vitro trial and spectrophotometric measurements will be taken. The release of drugs loaded into nanofibers are slower due to the wide surface area of the nanofibers, which offers a more controlled drug release.Publication Metadata only Natural nanoantioxidant systems: Recent developments and future prospects(Serüven Yayınevi, 2023-01-01) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA D., AYAZ SEYHAN S.Publication Metadata only Natural-source bioceramics and controlled drug release applications(Nova Science Publishers, 2023-01-01) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA D., AYAZ SEYHAN S.; Bartul , Zacharie; Bartul , Zachariehis volume contains eight chapters that detail advances in nanotechnology. Chapter One provides a thorough understanding of the effects of optical cavities and plasmonics and their applications. Chapter Two focuses on various nanocarrier approaches that evolved in recent times, the challenges, and future perspectives in ocular drug delivery systems. Chapter Three provides a comprehensive overview of the synthesis, properties, and particularly energy applications of elemental boron (EB) and boron-based hybrid nanomaterials using electrosynthesis techniques. Chapter Four summarizes the improvements in clinical diagnosis, detection, and therapeutic applications of nanoparticles against HBV and HCV viral infections. Chapter Five aims to determine the influence of the addition of metallic iron nanoparticles on the removal of lindane and the generation of bioelectricity in a soil slurry bioelectrochemical reactor (SSBER). Chapter Six provides information on various literature studies reported on drug release studies of naturally-synthesized hydroxyapatite (HA) composites. Chapter Seven sheds light on updated patents and advancements in nanosuspension technology, encompassing diverse drug molecules, instrumental techniques, and characterization parameters. Lastly, Chapter Eight investigates a piezoelectric actuator with coded control for use in nano research.Publication Metadata only Preparation and characterization of silver-doped hydroxyapatite from seashell by different methods(2018-09-08) AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; , Ayaz Seyhan S., Bilğiç Alkaya D., Öztürk B. N., Cesur S., Topsakal A., Oktar F. N., Gündüz O.Publication Metadata only Hydroxyapatıte is bıomaterıals: its chemıcal synthesıs characterızatıon shell of cypaea annulus(2018-09-08) BİLĞİÇ ALKAYA, DİLEK; AYAZ SEYHAN, SERAP; CESUR, SÜMEYYE; OKTAR, FAİK NÜZHET; GÜNDÜZ, OĞUZHAN; Bilğiç Alkaya D., Ayaz Seyhan S., Öztürk B. N., Cesur S., Topsakal A., Oktar F. N., Gündüz O.Publication Open Access The Determination of The Acidity Constants and The Stability Constants of Flavokermesic Acid Complexes with Tin(II) and Aluminium(III) Ions by Potentiometric Method(MARMARA UNIV, FAC PHARMACY, 2015-04-09) AYAZ SEYHAN, SERAP; Seyhan, Serap Ayaz; Dolen, EmreNatural dyestuffs has been revived because of the fact that many of the synthetic dyestuffs are carcinogenic, toxic and their waste leads to environmental pollution. Thus, their usage has accelerated in the field of food, medicine, cosmetics and textile dyeing industry. Natural dyestuffs are soluble organic compounds obtained from plants, animals, lichens and fungi. The insect that have been and are still used today as sources of red textiles dyes, paint, pigment, food and pharmaceutical colorants are all classified in the super family Coccoidea of the class Homoptera. Flavokermesic acid (laccaic acid D) is a natural dyestuff obtained from this insect. In this study, the protonation constants of flavokermesic acid that acquired from kermes insect and the stability constants of complexes with metal ions were determined by potentiometric method.Publication Metadata only Synthesis of medicinal plant based bioactive electrospun nanofibrous mats and their effect on the antioxidant activity(2022-06-24) AYAZ SEYHAN, SERAP; GÜNDÜZ, OĞUZHAN; BİLĞİÇ ALKAYA, DİLEK; Demirel A. B., AYAZ SEYHAN S., BİLĞİÇ ALKAYA D., CESUR S., GÜNDÜZ O.Publication Open Access