Person: DOĞAN, BAŞAK
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DOĞAN
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BAŞAK
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Publication Open Access Microbial composition and non-surgical periodontal treatment of aggressive periodontitis: Two case reports(2019) DOĞAN, BAŞAK; Dilek MAMAKLIOĞLU;Bahar EREN KURU;Maribasappa KARCHED;BAŞAK DOĞANThe objective of this case report was to characterize the subgingival microbiological profiles of two patients with generalized aggressive periodontitis (GAgP) and to evaluatethe clinical outcomes of non-surgical periodontal treatment(NSPT) over a 6-months period. Pooled subgingival samplesof two patients who referred to our clinic and diagnosed withGAgP were collected and analyzed for the presence of 300species/phlotypes using Human Oral Microbe IdentificationMicroarray analysis. NSPT was performed within 3-week period. Clinical parameters were measured at baseline, 3 and6 months after NSPT. Recall visits were performed every 2weeks during the first 3 months and every 4 weeks up to 6months. All samples harboured a total of 61 species and 32species were common in both patients. First patient had 17and the other had 12 distinct species. High levels of Filifactor alocis, Porpyromonas gingivalis, Campylobacter concisusand rectus, Fusobacterium nucleatum and Desulfobulbusspp. were detected in both patients while Aggregatibacter actinomycetemcomitans was found in none of them. Six monthsafter NSPT, all clinical parameters were improved in two A. actinomycetemcomitans-negative GAgP patients. In addition towell-recognized periodontal pathogens the presence of highlevels of Filifactor alocis and Desulfobulbus spp. seem to beassociated with GAgP.Publication Metadata only The relationship between vitamin D receptor gene polymorphisms and periodontitis in turkish individuals with type 2 diabetes mellitus(2022-07-01) DOĞAN, BAŞAK; MEGA TİBER, PINAR; Yildiz A. S., Ustundag F. D., Tiber P., Dogan B.© 2022 Wolters Kluwer Medknow Publications. All rights reserved.Background and Aim: Vitamin D receptor (VDR) gene polymorphisms have been implicated in the pathogenesis of many diseases, such as periodontitis and diabetes mellitus (DM). The present study aimed to evaluate the distributions of VDR polymorphisms in diabetic individuals with healthy periodontium (DMH), diabetic individuals with periodontitis (DMP), nondiabetic individuals with healthy periodontium (H), and nondiabetic individuals with periodontitis (P). Material and Methods: A total of 200 individuals (DMH = 40, DMP = 60, H = 40, and P = 60) were recruited. All clinical periodontal parameters, demographical, and biochemical variables were recorded. Blood samples were collected, and genomic DNA was isolated by Purelink® Genomic DNA Mini Kit. Genotyping of VDR polymorphisms ApaI, BsmI, FokI, and TaqI were determined by real-time polymerase chain reaction (PCR) using allele-specific probes. Results: The distribution of the BsmI variant showed differences between DMH and H groups (P = 0.034). In addition, carrying the GG genotype (OR = 0.317; 95% CI = 0.126-0.797; P = 0.013) and the G allele (OR = 2.373; 95% CI = 1.203-4.681; P = 0.012) increased the risk of type 2 DM. Moreover, it was determined that the frequency of CC genotype of FokI variant was higher in DMP compared to DMH (P = 0.046). It was determined that having the CC genotype (OR = 2.706; 95% CI = 1.185-6.176; P = 0.017) and the C allele (OR = 1.917; 95% CI = 0.995-3.694; P = 0.049) increased the risk of periodontitis among diabetic individuals. No differences were detected among groups in the genotype and allele distributions of ApaI and TaqI variants (P > 0.05). Conclusions: The present study showed that the BsmI variant was a risk factor for DM among periodontally healthy individuals and the FokI variant for periodontitis among diabetic individuals.Publication Metadata only Yaşlı Bireylerde Cerrahi Olmayan Periodontal Tedavi Yaklaşımı(Türkiye Klinikleri Yayınevi, 2022-12-01) ÖZTÜRK ÖZENER, HAFİZE; AĞRALI, ÖMER BİRKAN; DOĞAN, BAŞAK; Öztürk Özener H., Ağralı Ö. B., Doğan B.Publication Open Access Different scaling and root planing strategies in Turkish patients with aggressive periodontitis: A randomized controlled clinical trial(2022-05-01) DOĞAN, BAŞAK; Mamaklioglu D., Karched M., KURU L., Kuru B., Asikainen S., DOĞAN B.Objectives The aim of this study was to compare clinical, cytokine and microbiological responses after quadrant-based scaling and root planing (Q-SRP), full-mouth SRP (FM-SRP) and full-mouth disinfection (FMD) in patients with generalized aggressive periodontitis (GAgP), which is currently termed as generalized stage-III and grade-C periodontitis. Methods Forty-two patients with GAgP were randomly assigned into groups as Q-SRP, FM-SRP or FMD with chlorhexidine. Clinical parameters were recorded, and gingival crevicular fluid (GCF) and subgingival plaque samples were collected at baseline, 3 and 6 months after treatment. GCF levels of interleukin (IL)-1 beta and IL-17 were analysed using ELISA. Quantities of six bacterial species were determined using qPCR. Results Clinical parameters improved significantly in all groups at 3 and 6 months (p 6 mm was lower in the FMD than Q-SRP group at 3 and 6 months (p < 0.05). FMD showed significantly higher percentage of pocket closure compared with Q-SRP and FM-SRP at both 3 and 6 months after treatment (p < 0.05). The IL-1 beta levels decreased only in the FMD group (p < 0.05), whereas no changes were found in IL-17 levels in any group. The levels of five out of six bacterial species decreased at 3 and/or 6 months only in the FMD group (p < 0.05). Conclusions The FMD treatment appears to offer superior outcome than Q-SRP and could be the first choice for patients with GAgP.Publication Open Access Evaluation of knowledge, anxiety levels and attitudes of dental students about the COVID-19 outbreak different light sources(2022-01-01) DOĞAN, BAŞAK; SELMAN A. E., DOĞAN B.Amaç: Bu çalışmanın amacı, Marmara Üniversitesi Diş Hekimliği Fakültesi 5. sınıf öğrencilerinin COVID-19 ile ilgili bilgilerini, kaygı düzeylerini, tutum ve davranışlarını değerlendirmektir. Gereç ve Yöntem: Çalışma için COVID-19 ile ilgili 5 farklı çalışmadan elde edilen 26 soruluk yeni bir anket kullanıldı. Hazırlanan çevrimiçi anket 18 Mart 2021 tarihinde Marmara Üniversitesi Diş Hekimliği Fakültesi kliniklerinde hasta bakan son sınıf öğrencilerine gönderildi. Elde edilen verilerin analizinde SPSS 23.0 paket programı kullanıldı. Bulgular: Çalışmaya Marmara Üniversitesi Diş Hekimliği Fakültesi’nde 5. sınıfta eğitim gören öğrenciler dahil edildi ve öğrencilerin %92,9’u çalışmaya katıldı. Öğrencilerin %80’inden fazlası COVID-19’un hava ve temas yoluyla bulaştığını belirtti. Kliniklerde çapraz enfeksiyon sebepleri ve hastalığın klinikte yayılmasının önlenmesi için uygulanması gereken ek koruyucu önlemler öğrencilerin büyük çoğunluğu tarafından bilinmekteydi. Öğrencilerin COVID-19 ile ilgili bilgileri ve tutumları genel olarak cinsiyete göre farklılık göstermemekteydi (p>0.05). Katılımcıların %77.8’inin COVID-19 ile ilgili bilgilerini haberler aracılığı ile elde ettiği görüldü. Öğrencilerin çoğunluğunun COVID-19 ile ilgili kaygılarının orta düzeyde olduğu görüldü. Sonuç: Diş hekimliği son sınıf öğrencilerinin az da olsa bir kısmının COVID-19 hakkındaki bilgilerinin ve uygulamalarının yetersiz olması risk oluşturan bir durumdur. Öğrencilerin bilgilerinin sürekli güncellenmesi ve kaygı durumlarının kontrol altına alınması gerekmektedir.Publication Open Access Treatment of multiple adjacent gingival recessions using leucocyte- and platelet-rich fibrin with coronally advanced flap: a 12-month split-mouth controlled randomized clinical trial(2024-05-01) KURU, LEYLA; DOĞAN, BAŞAK; Yavuz A., Güngörmek H. S., Kuru L., Doğan B.Objective: This split-mouth randomized study aimed to assess efficacy of leucocyte-platelet-rich fibrin (L-PRF) versus connective tissue graft (CTG) in achieving root coverage (RC) for multiple adjacent gingival recessions (MAGRs) throughout 12-month period. Materials and methods: The study enrolled 59 teeth from 12 patients with Miller Class I MAGRs ≥ 2 mm on bilateral or contralateral sides. Patients were randomly assigned to receive coronally advanced flap (CAF) with either CTG (control) or L-PRF (test) treatment. Various parameters, including plaque and gingival index, clinical attachment level, recession depth, probing depth, recession width (RW), papilla width (PW), keratinized tissue width (KTW), gingival thickness (GT), percentage of RC, complete root coverage (CRC), and location of the relative gingival margin concerning the cemento-enamel junctions (GMCEJ) after CAF, were recorded at baseline, 3-, 6-, and 12-months post-surgery. On June 29, 2021 the study was registred to ClinicalTrials.gov (NCT04942821). Results: Except KTW and GT gain, all clinical parameters, RC, and CRC were similar between the groups at all follow-up periods (p > 0.05). The higher GT and KTW gains were detected in the control group compared to test group at 12 months (p < 0.05). Both RC and CRC were positively associated with initial PW and GMCEJ, but negatively with initial RW (p < 0.05). Conclusions: The current study concludes that L-PRF were equally effective as CTG in treating MAGRs in terms of RC and CRC. Additionally, RC and CRC outcomes appeared to be influenced by GMCEJ, PW, and RW. Clinical relevance: L-PRF could represent a feasible substitute for CTG in treating MAGRs.Publication Open Access Clinical and biochemical effects of smoking on non-surgical periodontal treatment in grade III stage C periodontitis patients(2023-03-01) DOĞAN, BAŞAK; Arıkan V., Görgülü N. G., Doğan B.Objective: The purpose of this study was to evaluate the effect of smoking on clinical parameters and the serum and saliva levels of RANKL, OPG, and IL-34 in periodontitis stage III grade C (III-C) patients after non-surgical periodontal treatment (NSPT). Methods: A total of 60 subjects, 40 periodontitis-III-C patients (20 smokers and 20 non-smokers) and 20 non-smoker periodontally healthy individuals, were included. All clinical periodontal parameters were recorded, and unstimulated saliva and serum samples were collected from all patients at baseline, but at 1 and 3 months only from periodontitis patients (N=40). Saliva and serum levels of RANKL, OPG, and IL-34 were analyzed by ELISA. Results: At baseline only whole mouth probing depth (PD) and percent of sites with PD>5mm were higher in smokers than non-smoker periodontitis patients (p<.05). All periodontal measurements significantly improved in both periodontitis groups after NSPT (p<.001). After NSPT, the reduction in gingival index (GI), bleeding on probing (BOP), and mean PD in sites initially PD≥5mm were lower in smokers than nonsmoker periodontitis patients (p>.05). Only saliva IL-34 levels were higher in all-periodontitis patients than healthy individuals (p=.001) and decreased in both periodontitis groups after NSPT (p<.05). Moreover, elevated serum RANKL level was detected in smokers compared to nonsmoker periodontitis or healthy ones at baseline (p<.05). Serum RANKL levels exhibited no change after NSPT in either periodontitis groups. Conclusions: The smokers are less responsive to NSPT, and saliva IL-34 can be a potential inflammatory marker of periodontitis-III-C. Moreover, high serum RANKL levels are associated with smoking.