Publication: Clinical and biochemical effects of smoking on non-surgical periodontal treatment in grade III stage C periodontitis patients
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Date
2023-03-01
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Abstract
Objective: The purpose of this study was to evaluate the effect of smoking on clinical parameters and the serum and saliva levels of RANKL,
OPG, and IL-34 in periodontitis stage III grade C (III-C) patients after non-surgical periodontal treatment (NSPT).
Methods: A total of 60 subjects, 40 periodontitis-III-C patients (20 smokers and 20 non-smokers) and 20 non-smoker periodontally healthy
individuals, were included. All clinical periodontal parameters were recorded, and unstimulated saliva and serum samples were collected from
all patients at baseline, but at 1 and 3 months only from periodontitis patients (N=40). Saliva and serum levels of RANKL, OPG, and IL-34 were
analyzed by ELISA.
Results: At baseline only whole mouth probing depth (PD) and percent of sites with PD>5mm were higher in smokers than non-smoker
periodontitis patients (p<.05). All periodontal measurements significantly improved in both periodontitis groups after NSPT (p<.001). After
NSPT, the reduction in gingival index (GI), bleeding on probing (BOP), and mean PD in sites initially PD≥5mm were lower in smokers than nonsmoker periodontitis patients (p>.05). Only saliva IL-34 levels were higher in all-periodontitis patients than healthy individuals (p=.001) and
decreased in both periodontitis groups after NSPT (p<.05). Moreover, elevated serum RANKL level was detected in smokers compared to nonsmoker periodontitis or healthy ones at baseline (p<.05). Serum RANKL levels exhibited no change after NSPT in either periodontitis groups.
Conclusions: The smokers are less responsive to NSPT, and saliva IL-34 can be a potential inflammatory marker of periodontitis-III-C. Moreover,
high serum RANKL levels are associated with smoking.
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Diş Hekimliği, Klinik Bilimler, Pedodonti, Sağlık Bilimleri, Dentistry, Clinical Sciences, Pedodontics, Health Sciences, Klinik Tıp (MED), Klinik Tıp, DİŞ HEKİMLİĞİ, ORAL CERRAHİ VE TIP, Clinical Medicine (MED), CLINICAL MEDICINE, DENTISTRY, ORAL SURGERY & MEDICINE, Periodontoloji, Ortodonti, Ağız Cerrahisi, Diş Hijyeni, Dişçilik Hizmetleri, Diş Hekimliği (çeşitli), Periodontics, Orthodontics, Oral Surgery, Dental Hygiene, Dental Assisting, Dentistry (miscellaneous), General Dentistry, periodontitis, smoking, interleukin-34, receptor activator of nuclear factor-kappa B ligand, osteoprotegerin
Citation
Arıkan V., Görgülü N. G., Doğan B., "Clinical and Biochemical Effects of Smoking on Non-Surgical Periodontal Treatment in Grade III Stage C Periodontitis Patients", CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.13, sa.1, ss.218-227, 2023