Person: DOĞAN, BAŞAK
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DOĞAN
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BAŞAK
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Publication Metadata only The relationship between vitamin D receptor gene polymorphisms and periodontitis in turkish individuals with type 2 diabetes mellitus(2022-07-01) DOĞAN, BAŞAK; MEGA TİBER, PINAR; Yildiz A. S., Ustundag F. D., Tiber P., Dogan B.© 2022 Wolters Kluwer Medknow Publications. All rights reserved.Background and Aim: Vitamin D receptor (VDR) gene polymorphisms have been implicated in the pathogenesis of many diseases, such as periodontitis and diabetes mellitus (DM). The present study aimed to evaluate the distributions of VDR polymorphisms in diabetic individuals with healthy periodontium (DMH), diabetic individuals with periodontitis (DMP), nondiabetic individuals with healthy periodontium (H), and nondiabetic individuals with periodontitis (P). Material and Methods: A total of 200 individuals (DMH = 40, DMP = 60, H = 40, and P = 60) were recruited. All clinical periodontal parameters, demographical, and biochemical variables were recorded. Blood samples were collected, and genomic DNA was isolated by Purelink® Genomic DNA Mini Kit. Genotyping of VDR polymorphisms ApaI, BsmI, FokI, and TaqI were determined by real-time polymerase chain reaction (PCR) using allele-specific probes. Results: The distribution of the BsmI variant showed differences between DMH and H groups (P = 0.034). In addition, carrying the GG genotype (OR = 0.317; 95% CI = 0.126-0.797; P = 0.013) and the G allele (OR = 2.373; 95% CI = 1.203-4.681; P = 0.012) increased the risk of type 2 DM. Moreover, it was determined that the frequency of CC genotype of FokI variant was higher in DMP compared to DMH (P = 0.046). It was determined that having the CC genotype (OR = 2.706; 95% CI = 1.185-6.176; P = 0.017) and the C allele (OR = 1.917; 95% CI = 0.995-3.694; P = 0.049) increased the risk of periodontitis among diabetic individuals. No differences were detected among groups in the genotype and allele distributions of ApaI and TaqI variants (P > 0.05). Conclusions: The present study showed that the BsmI variant was a risk factor for DM among periodontally healthy individuals and the FokI variant for periodontitis among diabetic individuals.Publication Metadata only Yaşlı Bireylerde Cerrahi Olmayan Periodontal Tedavi Yaklaşımı(Türkiye Klinikleri Yayınevi, 2022-12-01) ÖZTÜRK ÖZENER, HAFİZE; AĞRALI, ÖMER BİRKAN; DOĞAN, BAŞAK; Öztürk Özener H., Ağralı Ö. B., Doğan B.Publication Open Access Different scaling and root planing strategies in Turkish patients with aggressive periodontitis: A randomized controlled clinical trial(2022-05-01) DOĞAN, BAŞAK; Mamaklioglu D., Karched M., KURU L., Kuru B., Asikainen S., DOĞAN B.Objectives The aim of this study was to compare clinical, cytokine and microbiological responses after quadrant-based scaling and root planing (Q-SRP), full-mouth SRP (FM-SRP) and full-mouth disinfection (FMD) in patients with generalized aggressive periodontitis (GAgP), which is currently termed as generalized stage-III and grade-C periodontitis. Methods Forty-two patients with GAgP were randomly assigned into groups as Q-SRP, FM-SRP or FMD with chlorhexidine. Clinical parameters were recorded, and gingival crevicular fluid (GCF) and subgingival plaque samples were collected at baseline, 3 and 6 months after treatment. GCF levels of interleukin (IL)-1 beta and IL-17 were analysed using ELISA. Quantities of six bacterial species were determined using qPCR. Results Clinical parameters improved significantly in all groups at 3 and 6 months (p 6 mm was lower in the FMD than Q-SRP group at 3 and 6 months (p < 0.05). FMD showed significantly higher percentage of pocket closure compared with Q-SRP and FM-SRP at both 3 and 6 months after treatment (p < 0.05). The IL-1 beta levels decreased only in the FMD group (p < 0.05), whereas no changes were found in IL-17 levels in any group. The levels of five out of six bacterial species decreased at 3 and/or 6 months only in the FMD group (p < 0.05). Conclusions The FMD treatment appears to offer superior outcome than Q-SRP and could be the first choice for patients with GAgP.Publication Open Access Awareness, knowledge and attitude toward the relationship between periodontal health and pregnancy outcomes among obstetrician-gynecologist healthcare professionals in Turkey: Results of 11th Turkish-German Gynecological Association Congress based survey(2022-01-01) AĞRALI, ÖMER BİRKAN; DOĞAN, BAŞAK; Turabi R., AĞRALI Ö. B., DOĞAN B.© 2022 by the Turkish-German Gynecological Education and Research Foundation.Objective: The aim of this study was to evaluate the knowledge and practice behavior of Turkish obstetrician-gynecologists regarding oral healthcare during pregnancy and the association between periodontal disease and adverse pregnancy outcomes. Material and Methods: A cross-sectional study was conducted on randomly selected Turkish obstetrician-gynecologists using a questionnaire consisting of 26 questions during 11th Turkish-German Gynecological Association Congress. Participation in the survey was voluntary. Results: Out of 435 attendees approached, 382 (88%) of the gynecologists at the Congress participated in the written questionnaire. Most of the participants (96.1%) acknowledged a connection between oral health and pregnancy, and 77.5% agreed that periodontal disease may affect the outcome of pregnancy. Moreover, a high proportion of participants were aware of the clinical signs of periodontal diseases, mainly gingival bleeding (92.1%). However, almost 20% of participants thought that dental treatment could be performed safely in the first or last trimester of pregnancy. Only 36.9% of participants recommended guidance on dental examination for their patients during prenatal care. Conclusion: This study demonstrated that Turkish obstetrician-gynecologists have a relatively high degree of knowledge with respect to the relationship between periodontal disease and pregnancy outcomes, but practice behavior was poorly correlated with their knowledge. (J Turk Ger Gynecol Assoc 2022; 23: 275-86).Publication Open Access Treatment of multiple adjacent gingival recessions using leucocyte- and platelet-rich fibrin with coronally advanced flap: a 12-month split-mouth controlled randomized clinical trial(2024-05-01) KURU, LEYLA; DOĞAN, BAŞAK; Yavuz A., Güngörmek H. S., Kuru L., Doğan B.Objective: This split-mouth randomized study aimed to assess efficacy of leucocyte-platelet-rich fibrin (L-PRF) versus connective tissue graft (CTG) in achieving root coverage (RC) for multiple adjacent gingival recessions (MAGRs) throughout 12-month period. Materials and methods: The study enrolled 59 teeth from 12 patients with Miller Class I MAGRs ≥ 2 mm on bilateral or contralateral sides. Patients were randomly assigned to receive coronally advanced flap (CAF) with either CTG (control) or L-PRF (test) treatment. Various parameters, including plaque and gingival index, clinical attachment level, recession depth, probing depth, recession width (RW), papilla width (PW), keratinized tissue width (KTW), gingival thickness (GT), percentage of RC, complete root coverage (CRC), and location of the relative gingival margin concerning the cemento-enamel junctions (GMCEJ) after CAF, were recorded at baseline, 3-, 6-, and 12-months post-surgery. On June 29, 2021 the study was registred to ClinicalTrials.gov (NCT04942821). Results: Except KTW and GT gain, all clinical parameters, RC, and CRC were similar between the groups at all follow-up periods (p > 0.05). The higher GT and KTW gains were detected in the control group compared to test group at 12 months (p < 0.05). Both RC and CRC were positively associated with initial PW and GMCEJ, but negatively with initial RW (p < 0.05). Conclusions: The current study concludes that L-PRF were equally effective as CTG in treating MAGRs in terms of RC and CRC. Additionally, RC and CRC outcomes appeared to be influenced by GMCEJ, PW, and RW. Clinical relevance: L-PRF could represent a feasible substitute for CTG in treating MAGRs.Publication Open Access Clinical and biochemical effects of smoking on non-surgical periodontal treatment in grade III stage C periodontitis patients(2023-03-01) DOĞAN, BAŞAK; Arıkan V., Görgülü N. G., Doğan B.Objective: The purpose of this study was to evaluate the effect of smoking on clinical parameters and the serum and saliva levels of RANKL, OPG, and IL-34 in periodontitis stage III grade C (III-C) patients after non-surgical periodontal treatment (NSPT). Methods: A total of 60 subjects, 40 periodontitis-III-C patients (20 smokers and 20 non-smokers) and 20 non-smoker periodontally healthy individuals, were included. All clinical periodontal parameters were recorded, and unstimulated saliva and serum samples were collected from all patients at baseline, but at 1 and 3 months only from periodontitis patients (N=40). Saliva and serum levels of RANKL, OPG, and IL-34 were analyzed by ELISA. Results: At baseline only whole mouth probing depth (PD) and percent of sites with PD>5mm were higher in smokers than non-smoker periodontitis patients (p<.05). All periodontal measurements significantly improved in both periodontitis groups after NSPT (p<.001). After NSPT, the reduction in gingival index (GI), bleeding on probing (BOP), and mean PD in sites initially PD≥5mm were lower in smokers than nonsmoker periodontitis patients (p>.05). Only saliva IL-34 levels were higher in all-periodontitis patients than healthy individuals (p=.001) and decreased in both periodontitis groups after NSPT (p<.05). Moreover, elevated serum RANKL level was detected in smokers compared to nonsmoker periodontitis or healthy ones at baseline (p<.05). Serum RANKL levels exhibited no change after NSPT in either periodontitis groups. Conclusions: The smokers are less responsive to NSPT, and saliva IL-34 can be a potential inflammatory marker of periodontitis-III-C. Moreover, high serum RANKL levels are associated with smoking.