Person: GÜRBÜZ, BURÇAK
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GÜRBÜZ
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BURÇAK
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Publication Open Access Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity(2022-01-01) TOK, FATİH; GÜRBÜZ, BURÇAK; KAYMAKÇIOĞLU, BEDİA; TOK F., Doğan M. O. , GÜRBÜZ B., Koçyiğit-Kaymakçioğlu B.© 2022 Marmara University Press.In this study, new nine pyrazoline derivatives were synthesized from chalcone derivatives. The antimicrobial activity of nine pyrazoline derivatives to four standard bacterial strains (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis) and four standard yeast strains (Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis) was investigated by the microdilution method for in accordance with the Clinical and Laboratory Standards Institute (CLSI) standard, and the Minimal Inhibitory Concentration (MIC) values of these derivatives were determined. Among these derivatives; compounds 7 and 8 against bacterial strains and compounds 2 and 3 against yeast strains exhibited good antimicrobial activity.Publication Metadata only Synthesis and antimicrobial evaluation of new pyrazoline derivatives(2022-05-28) GÜRBÜZ, BURÇAK; TOK, FATİH; Tok F., Gürbüz B.Publication Metadata only Bazı Sülfonamid Türevlerinin Standart Bakteri Kökenlerine Karşı Antibakteriyel Etkileri(2020-12-20) GÜRBÜZ, BURÇAK; Gürbüz B., Türkmen C.Publication Metadata only Synergic potential of Pelargonium endlicherianum Fenzl. Essential oil and antibiotic combinations against Klebsiella pneumoniae(ELSEVIER, 2020) GÜRBÜZ, BURÇAK; Dumlupinar, Berrak; Karatoprak, Gokce Seker; Celik, Damla Damar; Gurer, Umran Soyogul; Demirci, Betul; Gurbuz, Burcak; Rayaman, Pervin; Kurtulus, Eda MerveIn this study we investigated antimicrobial activity against Klebsiella pneumoniae and the phagocytic functions of human leukocyte cells as revealed in an in vitro experimental model combining cefepime and gentamicin with Pelargonium endlicherianum Fenzl. essential oil treatments. The bactericidal effects of this essential oil and antibiotic combinations were dynamically detected by time-kill assay. To examine the function of this essential oil and antibiotics in permeating outer membrane barriers when used singly or in combination, a UV spectrophotometer was used, and morphologic images were captured by scanning electron microscopy. The antibacterial activity of the essential oil and antibiotics was assessed using broth microdilution and agar well diffusion. The combined effects of the essential oils of P. endlicherianum and gentamicin and cefepime were evaluated by means of the checkerboard method against K. pneumoniae. In the assays, fractional inhibitory concentration (FIC) values were calculated to characterize the interactions between the combinations. In the combinations of essential oil and antibiotics, the sensitivity of the bacteria to antibiotics increased and the antibiotics had a synergistic effect, and the antibacterial effect on the microorganisms increased. The cefepime + essential oil pair tested showed a synergistic effect (FIC <= 0.5), but the gentamicin + essential oil pair did not (FIC > 0.5-4.0). Thus, the cefepime + essential oil pair has been found to exhibit a synergistic effect against K. pneumoniae compared to the gentamicin + essential oil pair. According to the results obtained here, the combined use of essential oils with antibiotics can be applied as a treatment strategy to reduce the use of antibiotics, reduce side effects, and possibly reverse antibiotic resistance to these microorganisms in light of the increase in multiple antibiotic resistance. (c) 2020 SAAB. Published by Elsevier B.V. All rights reserved.Publication Open Access The cytotoxicity and the antimicrobial activities of arum italicum miller(2022-01-01) GÜRBÜZ, BURÇAK; Ulusoylu M., GÜRBÜZ B.© 2022 Marmara University Press.In this study, the cytotoxicity potential and antibacterial and antifungal activities of two different extracts of fresh leaves of Arum italicum Miller were investigated. The saponin extract and the alkaloid extract were investigated by Brine Shrimp (Artemia salina L.) lethality bioassay method for evaluation of cytotoxic effect. Umbelliferone was used as standard, and both of the extracts showed cytotoxic effect by the Brine Shrimp (Artemia salina L.) lethality bioassay method. According to the LC50 results, saponin extract was found to be the most active extract, and classifiable as moderate to highly toxic (LC50 237.1437 mg/mL-1). Although, the alkaloid extract was showed cytotoxic activity lower than Umbelliferone, LC50 750.1920 mg/mL-1 value was classifiable as mildly cytotoxic. Antibacterial and antifungal activities were tested by the agar well diffusion and tube dilution methods. 6 bacteria and 6 yeasts were used in the methods Meropenem and Fluconazole were the standards of the methods. The saponin extract was found to be effective against Staphylococcus epidermidis and Sthaphylococcus aureus compared with Meropenem. Both of the extracts were not found to be effective against fluconazole as antifungal activity point of view. According to the all studied activity results the saponin contents of the fresh leaves of the plant emphasizing the antimicrobial activity. And, both of the extracts have cytotoxic activity potential.Publication Metadata only Synthesis of new hydrazide-hydrazone derived from etophenamate and investigation of their antimicrobial activity(2023-10-22) GÜRBÜZ, BURÇAK; RAYAMAN, PERVİN; KARAKUŞ, SEVGİ; Saral Çakmak S., GÜRBÜZ B., RAYAMAN P., KARAKUŞ S.Recently since the emerging resistant strains to antimicrobial agents, the development of original antimicrobial agents in pharmaceutical chemistry has gained great importance. Antibiotic resistance is accepted as one of the greatest threatens against health worldwide. Since 1950s to now it is known that hydrazide-hydrazones have antimicrobial, anticancer, antitubercular, anticonvulsant etc., biological spectrum and biological activity (Polovic et al., 2019). Hydrazone derivatives are used in treatment and involved in the structure of many drugs such as nifuroxazide, nitrofurazone, bisanthren, budralazine, and levosimendan. Etophenamate was chosen as the starting compound to synthesis of 16 novel hydrazide-hydrazones. All of these derivatives were investigated in order to determine their antimicrobial activities. The structures of the synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental analysis. In this study, the antimicrobial activity of 16 hydrazide-hydrazone derivatives to 4 standard bacterial strains (Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Enterococcus faecalis ATCC 29212) and 4 standard yeast strains (Candida albicans ATCC 90028, Candida glabrata ATCC 90030, Candida parapsilosis ATCC 90018, Candida tropicalis KUEN 1021) was examined by the microdilution method in accordance with the Clinical and Laboratory Standards Institute (CLSI) standards, and the Minimal Inhibitory Concentration (MIC) values of these derivatives were determined. It was found that among these derivatives, 2c (725-0.35µg/ml) and 2p (1000-0.5µg/ml) possed antimicrobial activity against all of the 8 standard microorganism strains.