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EKREN, NAZMİ

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EKREN

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NAZMİ

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2018 - 20194
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End date: 2019 × Subject: Biomaterials ×

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Now showing 1 - 4 of 4
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    Cell studies on Electrohydrodynamic (EHD)-3D-bioprinted Bacterial Cellulose\Polycaprolactone scaffolds for tissue engineering
    (ELSEVIER SCIENCE BV, 2019) EKREN, NAZMİ; Altun, Esra; Ekren, Nazmi; Kuruca, Serap Erdem; Gunduz, Oguzhan
    The application of three-dimensional (3D) printed scaffolds for tissue engineering have gained significant attention in recent years. The biological activity of scaffolds used in tissue engineering applications depends on fabricating high-resolution patterns with fiber orientation and scale. In this study, Bacterial Cellulose (BC) and Polycaprolactone (PCL) composite scaffolds with the line spacing of 100 mu m are produced using Electrohydrodynamic (EHD)-3D-bioprinting technique. The composite scaffolds exhibit enhanced biocompatibility with facilitated cell attachment and proliferation in vitro. The results of this work have demonstrated that EHD-3D-bioprinting method shows great potential for the preparation of BC/PCL composite scaffold and patterns for tissue engineering with enhanced bioactivity. (C) 2018 Published by Elsevier B.V.
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    Developments of 3D polycaprolactone/beta-tricalcium phosphate/collagen scaffolds for hard tissue engineering
    (SPRINGER, 2019) İNAN, AHMET TALAT; Aydogdu, Mehmet O.; Mutlu, Bilcen; Kurt, Mustafa; Inan, Ahmet T.; Kuruca, Serap E.; Erdemir, Goekce; Sahin, Yesim M.; Ekren, Nazmi; Oktar, Faik N.; Gunduz, Oguzhan
    3D bioprinting provides an innovative strategy to fabricate a new composite scaffold material consisted in a porous and rough structure with using polycaprolactone (PCL), beta-tricalcium phosphate (beta-TCP), and collagen as a building block for tissue engineering. We investigated the optimization of the scaffold properties based on the beta-TCP concentration using 3D bioprinting method. Computer-aided drawing was applied in order to digitally design the scaffolds while instead of solid filaments, materials were prepared as a blend solution and controlled evaporation of the solvent during the bioprinting was enabled the proper solidification of the scaffolds, and they were successfully produced with well-defined porous structure. This work demonstrated the feasibility of complex PCL/beta-TCP/collagen scaffolds as an alternative in the 3D bioprinting engineering to the fabrication of porous scaffolds for tissue engineering.
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    3D printing of chitosan/ poly(vinyl alcohol) hydrogel containing synthesized hydroxyapatite scaffolds for hard-tissue engineering
    (ELSEVIER SCI LTD, 2019) KARTAL, İLYAS; Ergul, Necdet Mekki; Unal, Semra; Kartal, Ilyas; Kalkandelen, Cevriye; Ekren, Nazmi; Kilic, Osman; Chi-Chang, Lin; Gunduz, Oguzhan
    In recent years, 3D printed scaffolds becoming a widespread tool, which supports the repair mechanism of natural tissues. In order to support this knowledge, we used 3D printing methods to fabricated Chitosan (CH)/poly(vinyl alcohol)(PVA)-based scaffolds contains with a various ratio of hydroxyapatite (HA) (2.5, 5, 10, and 15 wt%). These composited scaffolds were further characterized for their chemical, morphological, mechanical, and biocompatibility properties. Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), swelling test, and compressive strength test were performed to reveal structural, mechanical and chemical characteristics of scaffolds. Among others, 15 wt% HA contained group demonstrated significantly superior and beneficial features in printing quality. Also, the results reveal that scaffolds have similar elastic modulus to natural bone. Bone morphogenetic protein-2 (BMP-2) protein was added to the most successful mechanically produced sample. As a result, it was shown that Chitosan/PVA/HA (15 wt%) with BMP-2 tissue scaffold could form a three-dimensional natural extracellular scaffold suitable for human mesenchymal stem cells. Altogether, these results show that hydroxyapatite added scaffolds produced may be a promising approach for bone tissue engineering applications.
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    Production of the novel fibrous structure of poly(epsilon-caprolactone)/tri-calcium phosphate/hexagonal boron nitride composites for bone tissue engineering
    (AUSTRALIAN CERAMIC SOCIETY, 2018) OKTAR, FAİK NÜZHET; Ozbek, Burak; Erdogan, Barkin; Ekren, Nazmi; Oktar, Faik Nuzhet; Akyol, Sibel; Ben-Nissan, Besim; Sasmazel, Hilal Turkoglu; Kalkandelen, Cevriye; Mergen, Ayhan; Kuruca, Serap Erdem; Ozen, Gunes; Gunduz, Oguzhan
    Nanofibrous composites of the poly(epsilon-caprolactone) (PCL), tricalcium phosphate (TCP), and hexagonal boron nitride (h-BN) with different compositions were manufactured by using an economical and non-complicated method called electrospinning. Produced fibrous structures showed no bead formation and had a clean surface. Characterization of the composites showed that particles were successfully mixed with polymer phase. High cell activity of SaOS-2 cells on the composites was observed with SEM images. In addition, fibrous scaffolds are biocompatible with human bone tissue and are highly degradable.