Person: BOZKURT, SÜHEYLA
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BOZKURT
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SÜHEYLA
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Publication Metadata only Isolated metastasis of breast cancer to the pituitary gland(MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2014) BOZKURT, SÜHEYLA; Eksi, Murat Sakir; Hasanov, Teyyub; Yilmaz, Baran; Akakin, Akin; Bayri, Yasar; Bozkurt, Suheyla Uyar; Kilic, TurkerPublication Open Access Mesenchymal stem cells differentiate to retinal ganglion-like cells in rat glaucoma model induced by polystyrene microspheres(2023-10-01) ERASLAN, MUHSİN; ÇERMAN, EREN; BOZKURT, SÜHEYLA; AKKOÇ, TUNÇ; ERASLAN M., ÇERMAN E., BOZKURT S., Genç D., Virlan A. T., Demir C. S., Akkoç T., Karaöz E., AKKOÇ T.Aim: The study aimed to evaluate the differentiation ability of intravitreally injected rat bone marrow-derived mesenchymal stem cells (rBM-MSCs) to retinal ganglion-like cells in a polystyrene microsphere induced rat glaucoma model. Materials and Methods: The glaucoma rat model was generated via intracameral injection of 7 microliter polystyrene microspheres. Green fluorescence protein-labeled (GFP) rBM-MSCs were transplanted intravitreally at or after induction of ocular hypertension (OHT), depending on the groups. By the end of the fourth week, flat-mount retinal dissection was performed, and labeled against Brn3a, CD90, GFAP, CD11b, Vimentin, and localization of GFP positive rBM-MSCs was used for evaluation through immunofluorescence staining and to count differentiated retinal cells by flow cytometry. From 34 male Wistar albino rats, 56 eyes were investigated. Results: Flow cytometry revealed significantly increased CD90 and Brn3a positive cells in glaucoma induced and with rBM-MSC injected groups compared to control(P = 0.006 and P = 0.003 respectively), sham-operated (P = 0.007 and P < 0.001 respectively), and only rBM-MSCs injected groups (P = 0.002 and P = 0.009 respectively). Immunofluorescence microscopy revealed differentiation of GFP labeled stem cells to various retinal cells, including ganglion-like cells. rBM-MSCs were observable in ganglion cells, inner and outer nuclear retinal layers in rBM-MSCs injected eyes. Conclusion: Intravitreally transplanted rBM-MSCs differentiated into retinal cells, including ganglion-like cells, which successfully created a glaucoma model damaged with polystyrene microspheres. Promisingly, MSCs may have a role in neuro-protection and neuro-regeneration treatment of glaucoma in the future.Publication Metadata only The comparative effects of local anaesthetics on wound healing in rats: Bupivacaine vs Levobupivacaine(Ondokuz Mayis Universitesi, 2016) BOZKURT, SÜHEYLA; Atalay Y.O., Umuroglu T., Yagmur C., Gogus F.Y., Bozkurt S.The aim of this study is to investigate the effects of local anaesthetic agents (bupivacaine and levobupivacaine) on wound healing in rats. Wistar albino rats were randomly assigned to three groups (n=10 per group); the control group, the bupivacaine group, and the levobupivacaine group. An incision measuring 5 cm in length was made over the dorsum in all groups. The incisions were infiltrated with 3 ml of normal saline in the control group, 3 ml of 0.25%bupivacaine in the bupivacaine group, and 3 ml of 0.25%levobupivacaine in the levobupivacaine group. Histopathological examinations and tensile strength measurements were performed on tissue samples taken from the incision line 14 days after infiltration. Epidermal and dermal regeneration scores were significantly lower in the levobupivacaine group compared with the bupivacaine and control groups (p<0.05). Granulation tissue thickness, angiogenesis, and tensile strength measurements were not significantly different between groups. Even though incomplete epidermal and dermal regeneration scores were attained using levobupivacaine, both bupivacaine and levobupivacaine had no negative effects on the overall clinical wound-healing process. © 2016 OMU.Publication Metadata only Effects of parenteral fish-oil emulsion (Omegaven) on cutaneous wound healing in rats treated with dexamethasone(SAGE PUBLICATIONS INC, 2007) BOZKURT, SÜHEYLA; Gercek, Arzu; Yildirim, Ozlem; Konya, Deniz; Bozkurt, Suheyla; Ozgen, Serdar; Kilic, Turker; Sav, Aydin; Pamir, NecmettinBackground: The aim was to assess wound healing when parenteral fish-oil emulsion is given to rats receiving dexamethasone. Methods: For 5 days after skin wounding, group S (control; n = 7) received saline 1 mL/kg intraperitoneal (IP); group D (n = 7), dexamethasone 0.2 mg/kg IP; and group DO (n = 9), dexamethasone 0.2 mg/kg IP plus 1 mL/kg Omegaven (Fresenius Kabi, Austria). Wound specimens were assessed for hydroxyproline level, wound depth, histology (epidermal/dermal regeneration, granulation tissue thickness, and angiogenesis), and. expression of transforming growth factor-P (TGF-P) and platelet-derived growth factor-AA (PDGF-AA). Results: Compared with D and DO specimens, controls had higher hydroxyproline (p <.01), deeper wounds (p <.05), and better histologic scores (p <.01 angiogenesis; others p <.05). There were no significant differences between the group D and DO means for hydroxyproline level, wound depth, or histologic scores (p >.05 for all). Controls had higher TGF-P expression scores than the other groups (p <.01 for both) and a higher PDGF-AA expression score, than group DO (p <.01). Groups D and DO had statistically similar TGF-p scores, but group D had a higher PDGF-AA score (2.71 +/- 0.75 vs 1.55 +/- 0.72, respectively; p <.05). Conclusions: According to the parameters we studied, adding parenteral. omega-3 and omega-6 fatty acids to the nutrition regimen of rats treated with dexamethasone does not seem to have adverse effects on wound healing, and effects on wound healing may not need to be considered when determining if these agents should be supplemented in nutrition support regimens.Publication Open Access Langerhans cell histiocytosis located in the spheno-orbital bone and the pons: Illustrative case(2023-07-01) ÇEKİÇ, EFECAN; KARAGÖZ, AHMET; SAKAR, MUSTAFA; KAÇAR, KADRİYE EBRU; BOZKURT, SÜHEYLA; DAĞÇINAR, ADNAN; ÇEKİÇ E., Karagoz A., SAKAR M., Senay R. E., AKAR K. E., BOZKURT S., DAĞÇINAR A.BACKGROUND This is a case of aggressive Langerhans cell histiocytosis (LCH) with an atypical intracranial location. OBSERVATIONS In this report, the authors present the diagnosis and treatment of a 12-year-old male patient diagnosed with LCH. The patient was admitted to the emergency department with left-sided facial palsy, and a solid lesion with mass effect in the pons was found. A biopsy was performed via suboccipital craniotomy, and the diagnosis was LCH. A chemotherapy regimen was started since the LCH sample was the resistant type. The patient showed improvement in his neurological deficit following treatment. LESSONS This rare localized and aggressive case’s diagnosis process and treatment choices may apply to future cases. https://thejns.org/doi/abs/10.3171/CASE22367.Publication Open Access Mass-forming extramedullary hematopoiesis mimicking Hodgkin's lymphoma(MARMARA UNIV, FAC MEDICINE, 2019-01-31) BOZKURT, SÜHEYLA; Kombak, Faruk Erdem; Uyar Bozkurt, Suheyla; Ozgumus, Toluy; Kaygusuz Atagunduz, IsikExtramedullary hematopoiesis (EMH) refers to the proliferation of hematopoietic precursors outside the bone marrow. EMH often presents as a mass lesion in several areas of the body. In this report, we present a case misdiagnosed and explain the cause of the diagnostic error.Publication Metadata only Gastrointestinal kanal patolojisinde tuzaklar(Kongre Kitabevi, 2022-01-01) ÇELİKEL, ÇİĞDEM; BOZKURT, SÜHEYLA; ÇELİKEL Ç., GÜLLÜOĞLU M., BOZKURT S., DOĞANAVŞARGİL YAKUT B., SAKA B., GÖKSEL S., YAMAN B.Publication Open Access A Case of Acute Myeloid Leukemia (FAB M2) with Inversion 16 Who Presented with Pelvic Myeloid Sarcoma(2014) KOÇ, AHMET; Çakan, Mustafa; Koç, Ahmet; Cerit, Kıvılcım; Bozkurt, Süheyla; Ergelen, Rabia; Vural, IrmakAcute leukemias are the most common childhood cancer in all age groups. Acute myeloid leukemias (AML) constitute about 15-20% of acute leukemias. Fatigability, pallor, fever, and bleeding are the most common presenting symptoms of AML. Hepatosplenomegaly and lymphadenopathy are commonly encountered during physical examination. In rare instances eruptions due to skin involvement and localized tumor masses (myeloid sarcoma) may be found. Myeloid sarcoma is especially seen in AML-M2 subtype. By cytogenetic analysis, in AML-M2 subtype t(8;21) is often seen and it is more probable to find inversion 16 in AML-M4Eos subtype. Herein, we present a 15-year-old girl whose initial symptom was abdominal pain for three days and her pathological sign was a large abdominal mass which was verified by imaging studies and diagnosed as myeloid sarcoma by biopsy. On bone marrow examination, she had diagnosis of AML-M2 and by cytogenetic analysis inversion 16 was positive. She was treated with AML-BFM 2004 protocol and she is being followed up in remission on her ninth month of the maintenance therapy.Publication Metadata only The histomorphological findings of kidneys after application of high dose and high-energy shock wave lithotripsy(POLISH UROLOGICAL ASSOC, 2015) BOZKURT, SÜHEYLA; Demir, Aslan; Turker, Polat; Bozkurt, Suheyla Uyar; Ilker, Yalcin NazmiIntroduction In this animal study, we reviewed the histomorphological findings in rabbit kidneys after a high number of high-energy shock wave applications and observed if there were any cumulative effects after repeated sessions. Material and methods We formed 2 groups, each consisting of 8 rabbits. Group 1 received 1 session and group 2 received 3 sessions of ESWL with a 7 day interval between sessions, consisting of 3500 beats to the left kidney and 5500 beats to the right kidney per session. The specimens of kidneys were examined histomorphologically after bilateral nephrectomy was performed. For statistical analysis, 4 groups of specimens were formed. The first and second groups received 1 session, 3500 and 5500 beats, respectively. The third and fourth groups received 3 sessions, at 3500 and 5500 beats per each session, respectively. The sections were evaluated under a light microscope to determine subcapsular thickening; subcapsular, intratubular and parenchymal hemorrhage; subcapsular, intersitital, perivascular and proximal ureteral fibrosis; paranchymal necrosis; tubular epithelial vacuolization; tubular atrophy; glomerular destruction and calcification. Results In histopathological examinations capsular thickening, subcapsular hematoma, tubuloepithelial vacuolisation, glomerular destruction, parenchymal hemorrhage, interstitial fibrosis, and perivascular fibrosis were observed in all groups. In statistical analysis, on the basis of perivascular fibrosis and tubular atrophy, there was a beats per session dependent increase of both. Conclusions The detrimental effects from ESWL are dose dependent but not cumulative for up to 3 sessions. Histopathological experimental animal studies will aid in understanding local and maybe, by means of these local effects, systemic effects.Publication Metadata only Acute megakaryoblastic leukemia mimicking small round cell tumor with novel t(1;5)(q21;p13)(BLACKWELL PUBLISHING, 2008) BOZKURT, SÜHEYLA; Bozkurt, Suheyla Uyar; Berrak, Su Gulsun; Tugtepe, Halil; Canpolat, Cengiz; Palanduz, Sukru; Tecimer, TulayAcute megakaryoblastic leukemia is a relatively rare form of acute leukemia that has heterogeneous blast morphology and karyotypic abnormalities. An 8-month-old boy with a retroperitoneal mass was diagnosed as having acute megakaryoblastic leukemia that initially presented as small round cell tumor of childhood. Bone marrow aspiration showed syncytial groups of atypical medium sized cells with scant cytoplasm and fine nuclear chromatin. Retroperitoneal mass biopsy showed several lymph nodes with cohesive clusters of neoplastic cells that demonstrated expression of Factor VIII. Flow cytometric analysis of the second bone marrow aspiration showed CD 61 positivity. Karyotypic analysis of bone marrow cells showed a novel translocation, (1;5)(q21;p13).