Person: KARĞIN, DİCLE
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KARĞIN
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DİCLE
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Publication Metadata only Probiotic Foods From Past To Present In Anatolian Culture(2016-09-07) İÇEN, HAYRUNİSA; KARĞIN, DİCLE; AKDUMAN, GÜL; İçen H., Karğın D., Akduman G., Güneş F. E.Publication Open Access Evaluation Of healthy nutrition index-2015, dental health and oral flora relationship in school-age children(2021-10-01) KARĞIN, DİCLE; OMURTAG KORKMAZ, BURCU İREM; KARĞIN D., OMURTAG KORKMAZ B. İ., MUNGAN C., AKYÜZ S. H.Objective: The aim of the study is to evaluate the role of diet quality and oral flora on the dental health in the childhood period. Methods: A cross-sectional study was carried out with the participation of 98 children aged 9-14 and their parents who applied to the Pedodontics Clinic Dental Faculty of Marmara University. The decayed, missing, filled tooth and surfaces and DMFT, DMFS indexes were determined through visual dental examination. Anthropometric measurements and saliva samples, as well as 24 h food consumption records, were taken from each child. Saliva samples were analysed microbiologically. To evaluate dietary quality from intakes Healthy Eating Index-2015 (HEI-2015) scores were calculated. Results: The mean age of children was 10.8±1.5 and study sample compromised 44.9% males and 55.1% females. 75% of the children had normal height and 58.2% of them had normal BMI according to World Health Organisation (WHO) references. The mean number of decayed tooth and surface was 3.07±2.35; 4.34±3.78 respectively and the mean number of DMFT and DMFS indexes were 5.88±2.31; 8.05±4.58 respectively. The mean number of decayed, missing, filled teeth and DMFT, DMFS scores were found to be higher in children with poor diets (according to HEI-2015) but the difference was not statistically significant (p>0.05). The presence of lactobacilli in saliva samples of 5.5% of the children was observed and children have lactobacilli in their saliva samples had more decayed teeth (p<0.05). Conclusion: The study findings illustrate the relationship between decay development and lactobacilli. Further studies with high sample sizes are needed to examine the diet quality and oral health.Publication Open Access Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats(2023-02-01) KARĞIN, DİCLE; YAVUZ, AYŞE NUR; ÇAM, MUHAMMET EMİN; AKTAÇ, ŞULE; Karğın D., Aktaç Ş., Yavuz A. N., Çam M. E.Cornelian cherry (Cornus mas L.) has been used for centuries as a traditional herbal medicine in Europe and Asia. In this study, we aimed to describe the effect of Cornus mas L. (C. mas) on the activity of the antioxidant enzymes and a detoxification agent in rats fed a high-fat diet. Forty-eight adult Sprague Dawley rats were randomly assigned to six groups of eight animals each: Standard diet (Control), High Fat Diet (HFD), HFD + C. mas (200 mg/kg/day; 8 weeks), HFD + Atorvastatin (20 mg/kg/day; 8 weeks), HFD post-treated with C. mas (200 mg/kg/day; 4 weeks), HFD posttreated with Atorvastatin (20 mg/kg/day; 4 weeks). The activity of the antioxidant enzymes, Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), detoxification agent glutathione (GSH), and oxidative stress parameter thiobarbituric acid reactive substances (TBARS) were measured in the liver tissues. GPx, SOD, and CAT enzyme levels were decreased in HFD groups compared to the control (p < 0.05). However, Cornus mas L. promoted antioxidant activity by increasing GPx, SOD, and CAT enzymes and It also reduced oxidative stress (as an increase in GSH) both in the HFD + C. mas group and the HFD post-treated C. mas group compared to the HFD group (p < 0.05). Our study showed that feeding a high-fat diet increases oxidative stress. Cornus mas L treatment improves antioxidant enzyme activity and oxidative stress parameters in the liver tissues of rats.Publication Open Access The relationship between social media use, eating attitude and body mass index among nutrition and dietetic female students: A cross-sectional study(ASOC ESPANOLA DIETISTAS NUTRICIONISTAS, 2021-04-06) KARĞIN, DİCLE; Aktac, Sule; Kargin, Dicle; Gunes, Fatma EsraIntroduction: This study aimed to investigate the relationship between media using habits, frequency and duration, and body mass index on eating attitudes. Material and Methods: The cross-sectional study was conducted with female students who received nutrition and dietetics education in Istanbul. A questionnaire consisting of a socio-demographic questionnaire, Eating Attitude Test (EAT-40), and Social Media Attitude Scale was applied to 1248 female volunteers by the face-to-face interview method. Results: It was found that 35.7% of the participants had abnormal eating attitudes and 89.6% showed a positive attitude towards social media. 93.7% of the group with abnormal eating attitudes indicated a positive attitude towards social media, 0.4% had a negative attitude and the difference was statistically significant (p=0.001). It was observed that a significant difference between EAT-40 and thought of an eating problem, having a social media membership, and spending time on social media (p<0.05). Conclusions: Social media have an effect on nutrition dietetics students on abnormal eating attitude; it did not show a significant effect on BMI.Publication Metadata only The nutritional properties of the kindergartens’ menus in anatolian side of Istanbul(2018-11-26) AKTAÇ, ŞULE; KARĞIN, DİCLE; SARIKAYA, BUSE; AKTAÇ Ş., KARĞIN D., SARIKAYA B., GÜNEŞ F. E.Publication Metadata only In Vivo Effects on Stress Protein, Genotoxicity, and Oxidative Toxicity Parameters in Oreochromis niloticus Tissues Exposed to Thiamethoxam(SPRINGER INTERNATIONAL PUBLISHING AG, 2021) KARĞIN, DİCLE; Temiz, Ozge; Kargin, Dicle; Cogun, Hikmet Y.This study aimed to observe the effect of toxicity of the pesticide thiamethoxam (TMX) at sublethal concentrations in the liver and brain of Oreochromis niloticus. In the experiment, fish were exposed to 50, 100, and, 150 mg/L with thiamethoxam for 48 h and 15 days. The superoxide dismutase (SOD), catalase (CAT), glutathione S-transferaz (GST), glutathione peroxidase (GPx), and ethoxyresorufin-O-deethylase (EROD) activities; and thiobarbituric acid reactive substance (TBARS), heat shock proteins 70 (HSP70), glutathione (GSH), and genotoxicity parameter 8-hydroxy-2 '-deoxyguanosine (8-OHdG) were analyzed by spectrophotometric methods and ELISA techniques. Depending on time and dose in TMX exposure in liver tissue, a significant decrease in GSH level; an increase in SOD, GST, GPx, and EROD enzyme activities; and HSP70, TBARS, and 8-OHdG levels was determined. In brain tissue, SOD, GST, and EROD enzyme activities, an increase in HSP70, TBARS, and 8-OHdG levels, and a decrease in CAT enzyme activity and GSH levels were determined. In this study, TMX in the concentrations used showed that changes in oxidative stress biomarkers, genotoxicity parameter 8-OHdG levels, and HSP70 levels caused toxic effects in the model organism. As a result of the study, the changes and protective effects of the antioxidant system and stress proteins at the cellular level were determined in sublethal doses of toxic effects caused by TMX in the vital organs of the organism. In this toxicological study, TMX exposure resulted in toxicity to O. niloticus liver and brain tissues, in addition, responses of biomarkers to time and concentrations were determined. As a result of this study, the potential toxic effects of the commonly used pesticide TMX will reveal both the ecological risks of the aquatic organism and the basic data of the safety and risk assessments of O. niloticus consumed as food for human health.Publication Metadata only Changes in Serum Physiological and Biochemical Parameters of Male Swiss Albino Mice After Oral Administration of Metal Oxide Nanoparticles (ZnO, CuO, and ZnO plus CuO)(SPRINGERNATURE, 2021) KARĞIN, DİCLE; Kargin, DicleZinc oxide (ZnO) and copper oxide (CuO) nanoparticles (NPs) are widely used in medicine and industrial fields. They have negative effects such as hematoxic, cytotoxic, and genotoxic on animals. This research aimed to investigate the blood physiological and biochemical responses induced by ZnO-NP and CuO-NP individually or in combination in male Swiss albino mice. For purpose, NPs were given to mice with 100 mu l of water by oral gavage for 14 days. Three sublethal NP dose groups (1, 5, 25 mg/kg/day) and one control group (only received 100 mu l of water) were used in the experiments and serum metabolite (glucose, total protein, total cholesterol, triglyceride, cortisol, blood urea nitrogen, immunoglobulin G, and M), ions (Na, K, Cl, Mg, and Ca), and enzyme (ALT, AST, ALP, and LDH) levels were measured. ZnO-, CuO-, and ZnO+CuO-NPs especially higher doses (5 and 25 mg/kg/day) decreased all serum metabolite (except blood urea nitrogen), ions, and ALP while these nanoparticles increased ALT, AST, LDH, and blood urea nitrogen. These increases/decreases in all serum parameters were generally higher in mice treated with the ZnO+CuO-NP mixture compared to the ZnO-NP and CuO-NP groups alone. The study shows that serum biochemistry profiles can be used as indicators to assess nanoparticle toxicity on lipid, protein, and energy metabolisms, immune and enzyme systems, ion regulation, and tissue functions.Publication Metadata only Evaluation of Nutrition Knowledge of Pregnant Women before and after Nutrition Education according to Sociodemographic Characteristics(TAYLOR & FRANCIS INC, 2018) KARĞIN, DİCLE; Aktac, Sule; Sabuncular, Guleren; Kargin, Dicle; Gunes, Fatma EsraThe aim of this cross-sectional study is to evaluate the effect of nutrition education on nutritional knowledge levels of pregnant women. The study was undertaken on a sample of pregnant women (i = 743) attending health centers in Istanbul for prenatal care. Nutrition knowledge scores were significantly higher in posttest (23.0) than pretest (16.0) after receiving nutrition education (p < .001). Significant differences in pretest (p < .05) but not posttest (p > .05) scores were found for factors, such as education level, work status, and the number of pregnancies; significant differences in both test scores were found for age and nutrition information (p < .05). In conclusion, pregnant women need to be given adequate and appropriate nutrition education for maternal and child health according to sociodemographic characteristics.