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TQ-Ox, a novel synthetic derivative of thymoquinone on ovarian cancer cells in vitro

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dc.contributor.authorÖZDEMİR, MÜCAHİT
dc.contributor.authorYALÇIN, BAHATTİN
dc.contributor.authorsKale E., Kale A., Bozali K., Gulgec A. S. , ÖZDEMİR M., YALÇIN B., Guler E. M.
dc.date.accessioned2022-12-27T05:58:44Z
dc.date.available2022-12-27T05:58:44Z
dc.date.issued2022-01-01
dc.description.abstract© 2022 Informa UK Limited, trading as Taylor & Francis Group.There are many studies in the literature on thymoquinone (TQ)-related cancer cells and models, and there is no relevant study investigating the efficacy of the oxime derivative of TQ (TQ-Ox). This study synthesized TQ-Ox and examined its cytotoxic, genotoxic and apoptotic properties in ovarian cancer cells. The structure TQ-Ox was confirmed with NMR. The cytotoxicity by luminometric ATP, intracellular reactive oxygen species (iROS) by fluorometric, intracellular calcium (iCa2+) by fluorometric, mitochondrial membrane potential (MMP) by flow cytometry, glutathione (GSH) levels with GSH/GSSG-Glo assay, DNA damage by comet assay, and apoptosis by acridine orange/ethidium bromide dye were determined. Concentrations of TQ-Ox were statistically increased cytotoxicity, DNA damage, apoptosis, iROS, and iCa2+ in a concentration-dependent manner (p < 0.001). Besides, MMP and GSH levels also decreased statistically significantly (p < 0.001) with increasing concentrations. TQ-Ox would be an effective treatment option by increasing cytotoxicity, genotoxicity, and apoptosis in ovarian carcinoma.
dc.identifier.citationKale E., Kale A., Bozali K., Gulgec A. S. , ÖZDEMİR M., YALÇIN B., Guler E. M. , "TQ-Ox, a novel synthetic derivative of thymoquinone on ovarian cancer cells in vitro", Natural Product Research, 2022
dc.identifier.doi10.1080/14786419.2022.2144298
dc.identifier.issn1478-6419
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85142369105&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/284144
dc.language.isoeng
dc.relation.ispartofNatural Product Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectBitki Koruma
dc.subjectFitopatoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectKimya
dc.subjectAnalitik Kimya
dc.subjectBiyokimya
dc.subjectBiyoinorganik Kimya
dc.subjectTemel Bilimler
dc.subjectAgricultural Sciences
dc.subjectAgriculture
dc.subjectPlant Protection
dc.subjectPhytopathology
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectChemistry
dc.subjectAnalytical Chemistry
dc.subjectBiochemistry
dc.subjectBioinorganic Chemistry
dc.subjectNatural Sciences
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectTemel Bilimler (SCI)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectBitki ve Hayvan Bilimleri
dc.subjectBİTKİ BİLİMLERİ
dc.subjectKİMYA, ANALİTİK
dc.subjectKİMYA, ORGANİK
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectAgriculture & Environment Sciences (AGE)
dc.subjectNatural Sciences (SCI)
dc.subjectLife Sciences (LIFE)
dc.subjectPLANT & ANIMAL SCIENCE
dc.subjectCHEMISTRY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectPLANT SCIENCES
dc.subjectCHEMISTRY, ANALYTICAL
dc.subjectCHEMISTRY, ORGANIC
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectFizik Bilimleri
dc.subjectBitki Bilimi
dc.subjectOrganik Kimya
dc.subjectPhysical Sciences
dc.subjectPlant Science
dc.subjectOrganic Chemistry
dc.subjectApoptosis
dc.subjectgenotoxicity
dc.subjectovarian cancer
dc.subjectthymoquinone-oxime
dc.titleTQ-Ox, a novel synthetic derivative of thymoquinone on ovarian cancer cells in vitro
dc.typearticle
dspace.entity.typePublication
local.avesis.id24f457ec-215a-4fdf-b2b1-489b7e5e0f0d
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication8ce578f0-69d2-471b-ae61-0d2526613f8f
relation.isAuthorOfPublication6405e2ff-5dd8-487d-a639-ac5fcc0832bc
relation.isAuthorOfPublication.latestForDiscovery8ce578f0-69d2-471b-ae61-0d2526613f8f

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