Publication: A pan-cancer atlas of differentially interacting hallmarks of cancer proteins
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Date
2022-11-01
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Abstract
Cancer hallmark genes and proteins orchestrate and drive carcinogenesis to a large extent, therefore, it is important to study these features in different cancer types to understand the process of tumorigenesis and discover measurable indicators. We performed a pan-cancer analysis to map differentially interacting hallmarks of cancer proteins (DIHCP). The TCGA transcriptome data associated with 12 common cancers were analyzed and the differential interactome algorithm was applied to determine DIHCPs and DIHCP-centric modules (i.e., DIHCPs and their interacting partners) that exhibit significant changes in their interaction patterns between the tumor and control phenotypes. The diagnostic and prognostic capabilities of the identified modules were assessed to determine the ability of the modules to function as system biomarkers. In addition, the druggability of the prognostic and diagnostic DIHCPs was investigated. As a result, we found a total of 30 DIHCP-centric modules that showed high diagnostic or prognostic performance in any of the 12 cancer types. Furthermore, from the 16 DIHCP-centric modules examined, 29% of these were druggable. Our study presents candidate systems\" biomarkers that may be valuable for understanding the process of tumorigenesis and improving personalized treatment strategies for various cancers, with a focus on their ten hallmark characteristics.
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Tıp, Dahili Tıp Bilimleri, Aile Hekimliği, Sağlık Bilimleri, Temel Tıp Bilimleri, Medicine, Internal Medicine Sciences, Family Medicine, Health Sciences, Fundamental Medical Sciences, SAĞLIK BAKIM BİLİMLERİ VE HİZMETLERİ, Klinik Tıp, Klinik Tıp (MED), TIP, GENEL & DAHİLİ, HEALTH CARE SCIENCES & SERVICES, CLINICAL MEDICINE, Clinical Medicine (MED), MEDICINE, GENERAL & INTERNAL, Tıbbi Terminoloji, Tıbbi Sekreterlik ve Transkripsiyon, Sağlık Bilgi Yönetimi, Sağlık Meslekleri (çeşitli), Genel Sağlık Meslekleri, Gözden Geçirme ve Sınav Hazırlığı, Patofizyoloji, Liderlik ve Yönetim, Temel Bilgi ve Beceriler, Toplum Sağlığı ve Evde Bakım, Bakım Planlaması, Değerlendirme ve Teşhis, Dahiliye, Sağlık Politikaları, Aile Sağlığı, Tıp (çeşitli), Genel Tıp, Medical Terminology, Medical Assisting and Transcription, Health Information Management, Health Professions (miscellaneous), General Health Professions, Review and Exam Preparation, Pathophysiology, Leadership and Management, Fundamentals and Skills, Community and Home Care, Care Planning, Assessment and Diagnosis, Internal Medicine, Health Policy, Family Practice, Medicine (miscellaneous), General Medicine, hallmarks of cancer, differential interactome, system biomarkers, druggability, personalized treatments, BIOMARKERS, hallmarks of cancer, differential interactome, system biomarkers, druggability, personalized treatments
Citation
Kori M., Ozdemir G. E., ARĞA K. Y., Sinha R., "A Pan-Cancer Atlas of Differentially Interacting Hallmarks of Cancer Proteins", JOURNAL OF PERSONALIZED MEDICINE, cilt.12, sa.11, 2022