Publication:
Studies on Some 3-Oxo-5-benzylidene-6-methyl-(4H) -2-substitutedpyridazines with Antinociceptive and Antiinflammatory Activities

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dc.contributor.authorGÖREN, MEHMET ZAFER
dc.contributor.authorsBalkan A., Özkanli F., ÜNSAL TAN O., GÖREN M. Z., TERZİOĞLU BEBİTOĞLU B.
dc.date.accessioned2023-05-22T11:10:48Z
dc.date.available2023-05-22T11:10:48Z
dc.date.issued2003-03-01
dc.description.abstractIn this study, some new 3-oxo-5-benzylidene-6-methyl-(4H)-2-substituted pyridazine derivatives have been prepared by the reaction of 5-substituted benzylidene-6-methyl-(4H)-pyridazin-3-one with several substituted benzoyl-methyl bromides. The structures of the compounds have been elucidated by IR, 1H-NMR and elemental analysis. Antinociceptive (only for compound IIIa) and anti-inflammatory activity studies were evaluated by using in vivo tests. The anti-inflammatory activity was studied by means of the \"carrageenan paw edema\", whereas the \"acetic acid writhing\" test was used to assess the antinociceptive activity. Qualitatively, compound IIIa was shown to exert anti-inflammatory effect as potent as phenylbutazone and antinociceptive effect similar to acetylsalicylic acid.
dc.identifier.citationBalkan A., Özkanli F., ÜNSAL TAN O., GÖREN M. Z., TERZİOĞLU BEBİTOĞLU B., "Studies on Some 3-Oxo-5-benzylidene-6-methyl-(4H) -2-substitutedpyridazines with Antinociceptive and Antiinflammatory Activities", Fabad Journal of Pharmaceutical Sciences, cilt.28, sa.1, ss.19-25, 2003
dc.identifier.endpage25
dc.identifier.issn1300-4182
dc.identifier.issue1
dc.identifier.startpage19
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=1842781165&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/289531
dc.identifier.volume28
dc.language.isoeng
dc.relation.ispartofFabad Journal of Pharmaceutical Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTROPİKAL TIP
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectTROPICAL MEDICINE
dc.subjectFarmasötik bilim
dc.subjectYaşam Bilimleri
dc.subjectPharmaceutical Science
dc.subjectLife Sciences
dc.subject3-Oxo-5-benzylidene-6-methyl-(4H)-2-substituted pyridazines
dc.subjectAnti-inflammatory activity
dc.subjectAntinociceptive activity
dc.subjectSynthesis
dc.titleStudies on Some 3-Oxo-5-benzylidene-6-methyl-(4H) -2-substitutedpyridazines with Antinociceptive and Antiinflammatory Activities
dc.typearticle
dspace.entity.typePublication
local.avesis.id0fd350a0-ac9b-4786-9150-da1a481009b4
local.indexed.atSCOPUS
relation.isAuthorOfPublicationf91c1cf5-3919-48eb-a772-35abafdc304e
relation.isAuthorOfPublication.latestForDiscoveryf91c1cf5-3919-48eb-a772-35abafdc304e

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