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Loading of tuberculosis drugs to nanofiber structures, fiber optimization

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dc.contributor.authorBİLĞİÇ ALKAYA, DİLEK
dc.contributor.authorAYAZ SEYHAN, SERAP
dc.contributor.authorCESUR, SÜMEYYE
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorsOnurlu H. İ., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O.
dc.date.accessioned2023-03-06T12:07:25Z
dc.date.available2023-03-06T12:07:25Z
dc.date.issued2019-06-28
dc.description.abstractuberculosis is a disease caused by a bacillus called mycobacterium tuberculosis which can be seen in other organs, especially in the lungs. Tuberculosis is an infectious, infectious, inflammatory, acute or chronic-trending bacterial infection. Since the treatment is insufficient with a single drug and the bacilli are resistant to this antibiotic, various antituberculosis drugs are used side by side during the treatment. Side-by-side use of the drugs breaks the resistance of the bacteria but creates a lot of side effects for the patient. We aim to reduce the existing side effects by loading the active agents of rifampicin, isoniazid, pyrazinamide and ethambutol, which are used as antituberculosis drugs, to a biodegradable nanofib. Primarily, PCL polymer material was dissolved in DMF: THF (v / v). After preparing PCL solution in 3%, 6%, 9%, 12% and 15% concentrations, optimization studies were performed by using electrospin device at various voltages. The SEM images of the obtained PCL fibers were examined and drug loading was performed at the suitable PCL concentration. In the planned study, FTIR images of the fibers loaded with the drug will be examined and controlled drug oscillations will be provided at the stomach and intestinal pH as an in vitro trial and spectrophotometric measurements will be taken. The release of drugs loaded into nanofibers are slower due to the wide surface area of the nanofibers, which offers a more controlled drug release.
dc.identifier.citationOnurlu H. İ., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O., \"Loading of tuberculosis drugs to nanofiber structures, fiber optimization\", 2. International Eurasian Conference on Biological and Chemical Sciences, Ankara, Türkiye, 28 - 29 Haziran 2019, ss.1
dc.identifier.startpage562
dc.identifier.urihttps://www.eurasianbiochem.org/bildiri%20taslaklar%C4%B1/Abstract_Book_EurasianBioChem_2019.pdf
dc.identifier.urihttps://hdl.handle.net/11424/287198
dc.language.isoeng
dc.relation.ispartof2. International Eurasian Conference on Biological and Chemical Sciences
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSağlık Bilimleri
dc.subjectMühendislik ve Teknoloji
dc.subjectHealth Sciences
dc.subjectEngineering and Technology
dc.subjectKlinik Tıp (MED)
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectClinical Medicine (MED)
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectAntituberculosis
dc.subjectbiodegradablepolymer
dc.subjectelectrospin
dc.subjectPCL
dc.subjectdrug release
dc.titleLoading of tuberculosis drugs to nanofiber structures, fiber optimization
dc.typeconferenceObject
dspace.entity.typePublication
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