Publication: Reappraisal of T1b gallbladder cancer (GBC): clinicopathologic analysis of 473 in situ and invasive GBCs and critical review of the literature highlights its rarity, and that it has a very good prognosis
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2023-02-01
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Abstract
There are highly conflicting data on relative frequency (2–32%), prognosis, and management of pT1b-gallbladder carcinoma (GBC), with 5-year survival ranging from > 90% in East/Chile where cholecystectomy is regarded as curative, versus 90%, similar to findings in the East. This supports the inclusion of pT1b in the \"early GBC\" category, as is typically done in high-incidence regions. Pathologic mis-staging of pT2 as pT1 is not uncommon. Cases should not be classified as pT1b unless extensive, preferably total, sampling of the gallbladder to rule out a subtle pT2 is performed. Critical appraisal of the literature reveals that the Western guidelines are based on either SEER or mis-interpretation of stage IB cases as \"pT1b.\" Although the prognosis of pT1b-GBC is very good, additional surgery (radical cholecystectomy) may be indicated, and long-term surveillance of the biliary tract is warranted.
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Tıp, Histoloji-Embriyoloji, Cerrahi Tıp Bilimleri, Patoloji, Yaşam Bilimleri, Moleküler Biyoloji ve Genetik, Sağlık Bilimleri, Temel Tıp Bilimleri, Biyokimya, Temel Bilimler, Medicine, Histology and Embryology, Surgery Medicine Sciences, Pathology, Life Sciences, Molecular Biology and Genetics, Health Sciences, Fundamental Medical Sciences, Biochemistry, Natural Sciences, Yaşam Bilimleri (LIFE), Biyoloji ve Biyokimya, PATOLOJİ, HÜCRE BİYOLOJİSİ, Life Sciences (LIFE), BIOLOGY & BIOCHEMISTRY, MOLECULAR BIOLOGY & GENETICS, PATHOLOGY, CELL BIOLOGY, Patoloji ve Adli Tıp, Moleküler Biyoloji, Hücre Biyolojisi, Pathology and Forensic Medicine, Molecular Biology, Cell Biology, Gallbladder carcinoma, Pathologic sampling, pT1b, Survival
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Pehlivanoglu B., Akkas G., Memis B., Basturk O., Reid M. D., Saka B., Dursun N., Bagci P., Balci S., Sarmiento J., et al., "Reappraisal of T1b gallbladder cancer (GBC): clinicopathologic analysis of 473 in situ and invasive GBCs and critical review of the literature highlights its rarity, and that it has a very good prognosis", Virchows Archiv, cilt.482, sa.2, ss.311-323, 2023