Publication: Could Ambroxol reduce cytokines in hepatic ischemia-reperfusion injury in rats
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Date
2022-01-01
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Abstract
OBJECTIVES: The aim of the study is to examine the effect of Ambroxol on TNF-α and IL-1β released after
liver ischemia-reperfusion injury.
BACKGROUND: Many drugs are being tried to reduce ischemia-reperfusion injury, which is life threating
problem after many liver surgeries. In this study, it was investigated whether Ambroxol reduces the release of
pro-infl ammatory cytokines released after liver ischemia-reperfusion injury.
METHODS: Twenty-four Wistar albino rats were divided into 3 groups as Control (CTR; n=8), hepatic
ischemia reperfusion (H-IR; n=8) and hepatic ischemia reperfusion+Ambroxol (H-IR+AMB; n=8). In
H-IR+AMB group, Ambroxol (30 mg/kg) was administered orally 30 minutes before ischemia period. In H-IR
and H-IR+AMB groups underwent 45 minutes of hepatic ischemia followed by a 60-minute reperfusion period.
After reperfusion period, tissue and blood samples were collected from euthanised animals. ALT, AST, ALP,
LDH, TNF-α, IL-1β concentrations and liver tissues were evaluated.
RESULTS: Serum ALT, ALP, AST, LDH, TNF-α and IL-1β values were lower in the H-IR+AMB group
compared to the H-IR group. In the histopathological examination, hepatocyte degeneration and congestion
in the H-IR group were higher than in the H-IR+AMB group.
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Keywords
Tıp, Sağlık Bilimleri, Temel Tıp Bilimleri, Medicine, Health Sciences, Fundamental Medical Sciences, TIP, GENEL & DAHİLİ, Klinik Tıp, Klinik Tıp (MED), MEDICINE, GENERAL & INTERNAL, CLINICAL MEDICINE, Clinical Medicine (MED), Aile Sağlığı, Temel Bilgi ve Beceriler, Genel Sağlık Meslekleri, Patofizyoloji, Dahiliye, Değerlendirme ve Teşhis, Tıp (çeşitli), Genel Tıp, Family Practice, Fundamentals and Skills, General Health Professions, Pathophysiology, Internal Medicine, Assessment and Diagnosis, Medicine (miscellaneous), General Medicine, Ambroxol, hepatic ischemia reperfusion, pro-inflammatory cytokines, rat, ALPHA-LIPOIC ACID, ISCHEMIA/REPERFUSION INJURY, ANTIOXIDANT, PROTECTS, BIOLOGY, Ambroxol, hepatic ischemia reperfusion, pro-infl ammatory cytokines, rat
Citation
Gulfekin C., Sehirli A. O., Cetinel S., Sayiner S., "Could Ambroxol reduce cytokines in hepatic ischemia-reperfusion injury in rats?", BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.123, sa.5, ss.381-384, 2022