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Could Ambroxol reduce cytokines in hepatic ischemia-reperfusion injury in rats

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dc.contributor.authorÇETİNEL, ŞULE
dc.contributor.authorsGulfekin C., Sehirli A. O., Cetinel S., Sayiner S.
dc.date.accessioned2023-07-17T08:59:15Z
dc.date.available2023-07-17T08:59:15Z
dc.date.issued2022-01-01
dc.description.abstractOBJECTIVES: The aim of the study is to examine the effect of Ambroxol on TNF-α and IL-1β released after liver ischemia-reperfusion injury. BACKGROUND: Many drugs are being tried to reduce ischemia-reperfusion injury, which is life threating problem after many liver surgeries. In this study, it was investigated whether Ambroxol reduces the release of pro-infl ammatory cytokines released after liver ischemia-reperfusion injury. METHODS: Twenty-four Wistar albino rats were divided into 3 groups as Control (CTR; n=8), hepatic ischemia reperfusion (H-IR; n=8) and hepatic ischemia reperfusion+Ambroxol (H-IR+AMB; n=8). In H-IR+AMB group, Ambroxol (30 mg/kg) was administered orally 30 minutes before ischemia period. In H-IR and H-IR+AMB groups underwent 45 minutes of hepatic ischemia followed by a 60-minute reperfusion period. After reperfusion period, tissue and blood samples were collected from euthanised animals. ALT, AST, ALP, LDH, TNF-α, IL-1β concentrations and liver tissues were evaluated. RESULTS: Serum ALT, ALP, AST, LDH, TNF-α and IL-1β values were lower in the H-IR+AMB group compared to the H-IR group. In the histopathological examination, hepatocyte degeneration and congestion in the H-IR group were higher than in the H-IR+AMB group.
dc.identifier.citationGulfekin C., Sehirli A. O., Cetinel S., Sayiner S., "Could Ambroxol reduce cytokines in hepatic ischemia-reperfusion injury in rats?", BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.123, sa.5, ss.381-384, 2022
dc.identifier.doi10.4149/bll_2022_060
dc.identifier.endpage384
dc.identifier.issn0006-9248
dc.identifier.issue5
dc.identifier.startpage381
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/9d11348a-ac75-4a82-bcba-8021f1a4deff/file
dc.identifier.urihttps://hdl.handle.net/11424/291304
dc.identifier.volume123
dc.language.isoeng
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectAile Sağlığı
dc.subjectTemel Bilgi ve Beceriler
dc.subjectGenel Sağlık Meslekleri
dc.subjectPatofizyoloji
dc.subjectDahiliye
dc.subjectDeğerlendirme ve Teşhis
dc.subjectTıp (çeşitli)
dc.subjectGenel Tıp
dc.subjectFamily Practice
dc.subjectFundamentals and Skills
dc.subjectGeneral Health Professions
dc.subjectPathophysiology
dc.subjectInternal Medicine
dc.subjectAssessment and Diagnosis
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Medicine
dc.subjectAmbroxol
dc.subjecthepatic ischemia reperfusion
dc.subjectpro-inflammatory cytokines
dc.subjectrat
dc.subjectALPHA-LIPOIC ACID
dc.subjectISCHEMIA/REPERFUSION INJURY
dc.subjectANTIOXIDANT
dc.subjectPROTECTS
dc.subjectBIOLOGY
dc.subjectAmbroxol
dc.subjecthepatic ischemia reperfusion
dc.subjectpro-infl ammatory cytokines
dc.subjectrat
dc.titleCould Ambroxol reduce cytokines in hepatic ischemia-reperfusion injury in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id9d11348a-ac75-4a82-bcba-8021f1a4deff
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationcd39227a-5dec-4ac2-818b-36ef87a2d15c
relation.isAuthorOfPublication.latestForDiscoverycd39227a-5dec-4ac2-818b-36ef87a2d15c

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