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Electrically triggered quercetin release from polycaprolactone/Bismuth ferrite microfibrous scaffold for skeletal muscle tissue

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dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsAyran M., Karabulut H., Deniz K. I., Akcanli G. C., Ulag S., Croitoru A., Tihăuan B., Sahin A., Ficai D., Gunduz O., et al.
dc.date.accessioned2023-03-30T06:03:03Z
dc.date.available2023-03-30T06:03:03Z
dc.date.issued2023-03-11
dc.description.abstractAbstract: Skeletal muscle tissue engineering presents a promising avenue to address the limitations pertaining to the regenerative potential of stem cells in case of injury or damage. The objective of this research was to evaluate the effects of utilizing novel microfibrous scaffolds, containing the compound quercetin (Q), on skeletal muscle regeneration. Morphological test results showed us that the combination of bismuth ferrite (BFO), polycaprolactone (PCL), and Q were bonded and well-ordered with each other, and a uniform microfibrous structure was obtained. Antimicrobial susceptibility testing of PCL/BFO/Q was conducted, and microbial reduction was found to be over 90% in the highest concentration of Q-loaded microfibrous scaffolds with the most inhibitory effect on S. aureus strains. Further, biocompatibility was investigated by performing MTT testing, fluorescence testing, and SEM imaging on mesenchymal stem cells (MSCs) to determine whether they could act as suitable microfibrous scaffolds for skeletal muscle tissue engineering. Incremental changes in the concentration of Q led to increased strength and strain, allowing muscles to withstand stretching during the healing process. In addition, electrically conductive microfibrous scaffolds enhanced the drug release capability by revealing that Q can be released significantly more quickly by applying the appropriate electric field, compared with conventional drug-release techniques. These findings suggest a possible use for PCL/BFO/Q microfibrous scaffolds in skeletal muscle regeneration by demonstrating that the combined action of both guidance biomaterials was more successful than Q itself acting alone.
dc.identifier.citationAyran M., Karabulut H., Deniz K. I., Akcanli G. C., Ulag S., Croitoru A., Tihăuan B., Sahin A., Ficai D., Gunduz O., et al., "Electrically Triggered Quercetin Release from Polycaprolactone/Bismuth Ferrite Microfibrous Scaffold for Skeletal Muscle Tissue.", Pharmaceutics, cilt.15, sa.3, 2023
dc.identifier.doi10.3390/pharmaceutics15030920
dc.identifier.issn1999-4923
dc.identifier.issue3
dc.identifier.urihttps://hdl.handle.net/11424/288006
dc.identifier.volume15
dc.language.isoeng
dc.relation.ispartofPharmaceutics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbiomaterials
dc.subjectquercetin
dc.subjectskeletal muscle
dc.subjectelectrospinning
dc.subjectelectrically drug delivery
dc.subjectantimicrobial activity
dc.titleElectrically triggered quercetin release from polycaprolactone/Bismuth ferrite microfibrous scaffold for skeletal muscle tissue
dc.typearticle
dspace.entity.typePublication
local.avesis.id4f8c1491-00ec-4db9-b9ea-abc936f453af
local.indexed.atPUBMED
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

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