Publication: Electrically triggered quercetin release from polycaprolactone/Bismuth ferrite microfibrous scaffold for skeletal muscle tissue
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Date
2023-03-11
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Abstract
Abstract: Skeletal muscle tissue engineering presents a promising avenue to address the limitations
pertaining to the regenerative potential of stem cells in case of injury or damage. The objective of
this research was to evaluate the effects of utilizing novel microfibrous scaffolds, containing the
compound quercetin (Q), on skeletal muscle regeneration. Morphological test results showed us
that the combination of bismuth ferrite (BFO), polycaprolactone (PCL), and Q were bonded and
well-ordered with each other, and a uniform microfibrous structure was obtained. Antimicrobial
susceptibility testing of PCL/BFO/Q was conducted, and microbial reduction was found to be over
90% in the highest concentration of Q-loaded microfibrous scaffolds with the most inhibitory effect on
S. aureus strains. Further, biocompatibility was investigated by performing MTT testing, fluorescence
testing, and SEM imaging on mesenchymal stem cells (MSCs) to determine whether they could act as
suitable microfibrous scaffolds for skeletal muscle tissue engineering. Incremental changes in the
concentration of Q led to increased strength and strain, allowing muscles to withstand stretching
during the healing process. In addition, electrically conductive microfibrous scaffolds enhanced the
drug release capability by revealing that Q can be released significantly more quickly by applying
the appropriate electric field, compared with conventional drug-release techniques. These findings
suggest a possible use for PCL/BFO/Q microfibrous scaffolds in skeletal muscle regeneration by
demonstrating that the combined action of both guidance biomaterials was more successful than Q
itself acting alone.
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Keywords
biomaterials, quercetin, skeletal muscle, electrospinning, electrically drug delivery, antimicrobial activity
Citation
Ayran M., Karabulut H., Deniz K. I., Akcanli G. C., Ulag S., Croitoru A., Tihăuan B., Sahin A., Ficai D., Gunduz O., et al., "Electrically Triggered Quercetin Release from Polycaprolactone/Bismuth Ferrite Microfibrous Scaffold for Skeletal Muscle Tissue.", Pharmaceutics, cilt.15, sa.3, 2023