Publication: Performance of Sysmex UF-5000 for candiduria screening
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2022-12-01
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In this study, we tested the performance of the Sysmex UF-5000 system to detect yeast-like cell
(YLC) counting to screen for candiduria. Urine samples were screened for leukocyte and yeast
amount by flow cytometry and results were compared with fungal culture results. A total of 56,749
urine samples were enrolled in this study. Urine culture and urinalysis of YLC data were used to
evaluate the performance of YLC in diagnosing candiduria. Different cut-off values (YLC. 5, 10,
20, 50, 100/µl) were evaluated. Youden index was used to determine the ideal cut-off value, and the
highest was 0.95 with 5 YLC/µl. When the cut-off value for YLC is 5 cells/µl, 95.15% of the samples
were “negative” with flow cytometry and culture (NPV:100%). In conclusion, detection of YLC by
flow cytometer (Sysmex UF-5000) can be a rapid alternative method to exclude candiduria prior to
urine culture.
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Yanılmaz Ö., Akşit İlki A., "Performance of Sysmex UF-5000 for candiduria screening.", The new microbiologica, cilt.45, sa.4, ss.292-295, 2022