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Fabrication of Amphotericin-B-loaded Sodium Alginate Nanoparticles for Biomedical Applications

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dc.contributor.authorULAĞ, SONGÜL
dc.contributor.authorŞENGÖR, MUSTAFA
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorsULAĞ S., Celik S. E., ŞENGÖR M., GÜNDÜZ O.
dc.date.accessioned2023-09-04T12:50:20Z
dc.date.available2023-09-04T12:50:20Z
dc.date.issued2022-12-01
dc.description.abstractIn this study, amphotericin-B (AMB)-loaded sodium alginate (SA) nanoparticles were fabricated using the electrospraying technique for biomedical applications. AMB is an antifungal agent and is poorly absorbed from the gastrointestinal tract due to its low aqueous solubility. Therefore, it should be given parenterally to treat systemic fungal infections. This study aims to transport it with nanoparticle formulations and observe the nanoparticle release behaviours. Scanning electron microscopy (SEM) images showed that nanoparticles of 0.5% SA fabricated at 37 kV had the most suitable particle diameter (93.36±24.386 nm) for loading 0.5, 1, and 3 ml of AMB. Fourier transform infrared spectroscopy (FTIR) results demonstrated that AMB successfully loaded into 0.5% SA nanoparticles. Drug release behaviours of the AMB-loaded particles indicated that AMB was released with a burst at the beginning, and release behaviour became sustainable after half an hour. The encapsulation efciencies of the diferent amounts of drug were calculated, and the results showed that the highest encapsulation efciency belonged to the 0.5% SA/1 AMB nanoparticles (42±1.23%).
dc.identifier.citationULAĞ S., Celik S. E., ŞENGÖR M., GÜNDÜZ O., "Fabrication of Amphotericin-B-loaded Sodium Alginate Nanoparticles for Biomedical Applications", BIONANOSCIENCE, cilt.12, sa.4, ss.1230-1237, 2022
dc.identifier.doi10.1007/s12668-022-01018-5
dc.identifier.endpage1237
dc.identifier.issn2191-1630
dc.identifier.issue4
dc.identifier.startpage1230
dc.identifier.urihttps://hdl.handle.net/11424/293078
dc.identifier.volume12
dc.language.isoeng
dc.relation.ispartofBIONANOSCIENCE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMühendislik ve Teknoloji
dc.subjectEngineering and Technology
dc.subjectMALZEME BİLİMİ, BİYOMATERYAL
dc.subjectMalzeme Bilimi
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectMATERIALS SCIENCE, BIOMATERIALS
dc.subjectMATERIALS SCIENCE
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectBiyomalzemeler
dc.subjectMalzeme Bilimi (çeşitli)
dc.subjectGenel Malzeme Bilimi
dc.subjectFizik Bilimleri
dc.subjectBiomaterials
dc.subjectMaterials Science (miscellaneous)
dc.subjectGeneral Materials Science
dc.subjectPhysical Sciences
dc.subjectAmphotericin-B
dc.subjectBiomedical
dc.subjectDrug release
dc.subjectElectrospraying
dc.subjectNanoparticle
dc.subjectSodium alginate
dc.titleFabrication of Amphotericin-B-loaded Sodium Alginate Nanoparticles for Biomedical Applications
dc.typearticle
dspace.entity.typePublication
local.avesis.id9a69fe57-60b3-462e-adff-d0e072ff647d
local.indexed.atWOS
local.indexed.atSCOPUS
relation.isAuthorOfPublication7694c253-e59a-4111-abfb-dcb9eed6d6f8
relation.isAuthorOfPublication290efe89-ff1c-49a8-aae2-5a7b727f68a1
relation.isAuthorOfPublication6f8fbd59-80b1-43bd-bfba-db1b1649c112
relation.isAuthorOfPublication.latestForDiscovery7694c253-e59a-4111-abfb-dcb9eed6d6f8

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