Publication: Morphological and biochemical investigation of the healing effects of exercise on high fat diet induced kidney and bladder damage
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Date
2022-10-01
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Abstract
Objective: The aim of this study was to evaluate the ameliorative effects of swimming training on renal and bladder damage caused by a highfatdiet (HFD) using morphological and biochemical measurements.Methods: Sprague Dawley rats were fed either standard chow (CONT, 6% fat) or HFD (45% fat) for 18 weeks, these rats were divided into twosubgroups at the last 6 weeks of the experiment. The exercise groups (CONT+EXC, HFD+EXC) were trained daily swimming sessions (1 h per dayfor 5 days/week) during the last 6 weeks. Kidney and bladder samples were prepared for light and electron microscopic examination at the endof experiment. Malondialdehyde, glutathione, interleukin-6, and tumor necrosis factor-α were measured by biochemically.Results: Regular morphology of the renal cortex and bladder mucosa was observed in the CONT and CONT +EXC groups. Degenerated renalcorpuscles and proximal tubules in the kidney and degenerated urothelium with leaky tight junctions and mast cell increase in the bladdermucosa were observed in the HFD group. Ameliorated renal cortex and bladder mucosa were observed in the HFD+EXC group. In addition,malondialdehyde, glutathione, interleukin-6, and tumor necrosis factor-α levels were also consistent with the histological findings.Conclusion: HFD-induced renal and bladder damage may be related to increased oxidative damage. It was observed that the histologicaldamage and altered oxidative stress parameters could be reversed by swimming training, and it is thought that moderate swimming exercisemay play a role in regulating oxidative stress.
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Tıp, Histoloji-Embriyoloji, Sağlık Bilimleri, Temel Tıp Bilimleri, Medicine, Histology and Embryology, Health Sciences, Fundamental Medical Sciences, Klinik Tıp (MED), Yaşam Bilimleri (LIFE), Klinik Tıp, Moleküler Biyoloji ve Genetik, TIP, GENEL & DAHİLİ, HÜCRE BİYOLOJİSİ, Clinical Medicine (MED), Life Sciences (LIFE), CLINICAL MEDICINE, MOLECULAR BIOLOGY & GENETICS, MEDICINE, GENERAL & INTERNAL, CELL BIOLOGY, Genel Sağlık Meslekleri, Patofizyoloji, Temel Bilgi ve Beceriler, Değerlendirme ve Teşhis, Dahiliye, Aile Sağlığı, Tıp (çeşitli), Genel Tıp, Hücre Biyolojisi, Yaşam Bilimleri, General Health Professions, Pathophysiology, Fundamentals and Skills, Assessment and Diagnosis, Internal Medicine, Family Practice, Medicine (miscellaneous), General Medicine, Cell Biology, Life Sciences, High fat diet, exercise, kidney, bladder
Citation
Açıkel Elmas M., Bingöl Özakpınar Ö., Kolgazi M., Şener G., Ercan F., "Morphological and Biochemical Investigation of the Healing Effects of Exercise on High Fat Diet Induced Kidney and Bladder Damage", CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.12, sa.4, ss.817-823, 2022