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Morphological and biochemical investigation of the healing effects of exercise on high fat diet induced kidney and bladder damage

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dc.contributor.authorBİNGÖL ÖZAKPINAR, ÖZLEM
dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsAçıkel Elmas M., Bingöl Özakpınar Ö., Kolgazi M., Şener G., Ercan F.
dc.date.accessioned2022-11-03T13:37:15Z
dc.date.available2022-11-03T13:37:15Z
dc.date.issued2022-10-01
dc.description.abstractObjective: The aim of this study was to evaluate the ameliorative effects of swimming training on renal and bladder damage caused by a highfatdiet (HFD) using morphological and biochemical measurements.Methods: Sprague Dawley rats were fed either standard chow (CONT, 6% fat) or HFD (45% fat) for 18 weeks, these rats were divided into twosubgroups at the last 6 weeks of the experiment. The exercise groups (CONT+EXC, HFD+EXC) were trained daily swimming sessions (1 h per dayfor 5 days/week) during the last 6 weeks. Kidney and bladder samples were prepared for light and electron microscopic examination at the endof experiment. Malondialdehyde, glutathione, interleukin-6, and tumor necrosis factor-α were measured by biochemically.Results: Regular morphology of the renal cortex and bladder mucosa was observed in the CONT and CONT +EXC groups. Degenerated renalcorpuscles and proximal tubules in the kidney and degenerated urothelium with leaky tight junctions and mast cell increase in the bladdermucosa were observed in the HFD group. Ameliorated renal cortex and bladder mucosa were observed in the HFD+EXC group. In addition,malondialdehyde, glutathione, interleukin-6, and tumor necrosis factor-α levels were also consistent with the histological findings.Conclusion: HFD-induced renal and bladder damage may be related to increased oxidative damage. It was observed that the histologicaldamage and altered oxidative stress parameters could be reversed by swimming training, and it is thought that moderate swimming exercisemay play a role in regulating oxidative stress.
dc.identifier.citationAçıkel Elmas M., Bingöl Özakpınar Ö., Kolgazi M., Şener G., Ercan F., "Morphological and Biochemical Investigation of the Healing Effects of Exercise on High Fat Diet Induced Kidney and Bladder Damage", CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.12, sa.4, ss.817-823, 2022
dc.identifier.doi10.33808/clinexphealthsci.1027516
dc.identifier.endpage823
dc.identifier.issn2459-1459
dc.identifier.issue4
dc.identifier.startpage817
dc.identifier.urihttps://dergipark.org.tr/en/pub/clinexphealthsci/issue/73168/1027516
dc.identifier.urihttps://hdl.handle.net/11424/282836
dc.identifier.volume12
dc.language.isoeng
dc.relation.ispartofCLINICAL AND EXPERIMENTAL HEALTH SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectHistoloji-Embriyoloji
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectHistology and Embryology
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectHÜCRE BİYOLOJİSİ
dc.subjectClinical Medicine (MED)
dc.subjectLife Sciences (LIFE)
dc.subjectCLINICAL MEDICINE
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectCELL BIOLOGY
dc.subjectGenel Sağlık Meslekleri
dc.subjectPatofizyoloji
dc.subjectTemel Bilgi ve Beceriler
dc.subjectDeğerlendirme ve Teşhis
dc.subjectDahiliye
dc.subjectAile Sağlığı
dc.subjectTıp (çeşitli)
dc.subjectGenel Tıp
dc.subjectHücre Biyolojisi
dc.subjectYaşam Bilimleri
dc.subjectGeneral Health Professions
dc.subjectPathophysiology
dc.subjectFundamentals and Skills
dc.subjectAssessment and Diagnosis
dc.subjectInternal Medicine
dc.subjectFamily Practice
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Medicine
dc.subjectCell Biology
dc.subjectLife Sciences
dc.subjectHigh fat diet
dc.subjectexercise
dc.subjectkidney
dc.subjectbladder
dc.titleMorphological and biochemical investigation of the healing effects of exercise on high fat diet induced kidney and bladder damage
dc.typearticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery44b61e5d-4045-4d63-926e-2f01c3ee5642

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