Publication: Inflammatory markers as predictors of atrial fibrillation recurrence: Exploring the c-reactive protein to albumin ratio in cryoablation patients
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Date
2023-09-30
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Abstract
BACKGROUND: Atrial fibrillation (AF) is a common cardiac rhythm disorder associated
with hemodynamic disruptions and thromboembolic events. While antiarrhythmic drugs are often
recommended as the initial treatment, catheter ablation has emerged as a viable alternative. However,
the recurrence of AF following ablation remains a challenge, and there is growing interest in exploring
inflammatory markers as predictors of recurrence. METHODS: This retrospective, cross-sectional
analysis included 249 patients who underwent cryoablation for paroxysmal AF. The relationship
between the ‘C-reactive protein (CRP) to albumin ratio (CAR)’ and AF recurrence was examined.
RESULTS: Two hundred and forty-nine patients with paroxysmal non-valvular atrial fibrillation were
included. They were divided into two groups: those without recurrence (Group 1) and those with
recurrence (Group 2). Significant differences were observed in age (57.2 ± 9.9 vs. 62.5 ± 8.4, p = 0.001)
and left atrial size (4.0 ± 0.5 vs. 4.2 ± 0.7, p = 0.001) between the two groups. In blood parameters,
significant differences were found in CRP (5.2 ± 1.3 vs. 9.4 ± 2.8, p < 0.001) and neutrophil counts
(5.1 ± 2.2 vs. 6.7 ± 3.6, p = 0.001). In univariate regression analysis, age (OR: 1.058, CI: 1.024–1.093,
p = 0.001), WBC count (OR: 1.201, CI: 1.092–1.322, p < 0.001), neutrophil count (OR: 1.239,
CI: 1.114–1.378, p = 0.001), CAR (OR: 1.409, CI: 1.183–1.678, p < 0.001), and left atrial diameter
(OR: 0.968, CI: 0.948–0.989, p = 0.002) showed significant associations with AF recurrence. CONCLUSIONS: Inflammation plays a crucial role in the initiation and progression of AF. This study
demonstrated that along with age, the CAR can serve as an independent predictor of AF recurrence
following cryoablation.
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Keywords
atrial fibrillation, C-reactive protein, CRP albumin ratio, cryoablation
Citation
Ozkan E., Elcik D., Barutcu S., Kelesoglu S., Alp M. E., Ozan R., Capar G., Turkmen O., Cinier G., Polat V., et al., "Inflammatory Markers as Predictors of Atrial Fibrillation Recurrence: Exploring the C-Reactive Protein to Albumin Ratio in Cryoablation Patients.", Journal of clinical medicine, cilt.12, sa.19, 2023