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Inflammatory markers as predictors of atrial fibrillation recurrence: Exploring the c-reactive protein to albumin ratio in cryoablation patients

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dc.contributor.authorKEPEZ, ALPER
dc.contributor.authorsOzkan E., Elcik D., Barutcu S., Kelesoglu S., Alp M. E., Ozan R., Capar G., Turkmen O., Cinier G., Polat V., et al.
dc.date.accessioned2023-10-18T08:42:20Z
dc.date.available2023-10-18T08:42:20Z
dc.date.issued2023-09-30
dc.description.abstractBACKGROUND: Atrial fibrillation (AF) is a common cardiac rhythm disorder associated with hemodynamic disruptions and thromboembolic events. While antiarrhythmic drugs are often recommended as the initial treatment, catheter ablation has emerged as a viable alternative. However, the recurrence of AF following ablation remains a challenge, and there is growing interest in exploring inflammatory markers as predictors of recurrence. METHODS: This retrospective, cross-sectional analysis included 249 patients who underwent cryoablation for paroxysmal AF. The relationship between the ‘C-reactive protein (CRP) to albumin ratio (CAR)’ and AF recurrence was examined. RESULTS: Two hundred and forty-nine patients with paroxysmal non-valvular atrial fibrillation were included. They were divided into two groups: those without recurrence (Group 1) and those with recurrence (Group 2). Significant differences were observed in age (57.2 ± 9.9 vs. 62.5 ± 8.4, p = 0.001) and left atrial size (4.0 ± 0.5 vs. 4.2 ± 0.7, p = 0.001) between the two groups. In blood parameters, significant differences were found in CRP (5.2 ± 1.3 vs. 9.4 ± 2.8, p < 0.001) and neutrophil counts (5.1 ± 2.2 vs. 6.7 ± 3.6, p = 0.001). In univariate regression analysis, age (OR: 1.058, CI: 1.024–1.093, p = 0.001), WBC count (OR: 1.201, CI: 1.092–1.322, p < 0.001), neutrophil count (OR: 1.239, CI: 1.114–1.378, p = 0.001), CAR (OR: 1.409, CI: 1.183–1.678, p < 0.001), and left atrial diameter (OR: 0.968, CI: 0.948–0.989, p = 0.002) showed significant associations with AF recurrence. CONCLUSIONS: Inflammation plays a crucial role in the initiation and progression of AF. This study demonstrated that along with age, the CAR can serve as an independent predictor of AF recurrence following cryoablation.
dc.identifier.citationOzkan E., Elcik D., Barutcu S., Kelesoglu S., Alp M. E., Ozan R., Capar G., Turkmen O., Cinier G., Polat V., et al., "Inflammatory Markers as Predictors of Atrial Fibrillation Recurrence: Exploring the C-Reactive Protein to Albumin Ratio in Cryoablation Patients.", Journal of clinical medicine, cilt.12, sa.19, 2023
dc.identifier.doi10.3390/jcm12196313
dc.identifier.issn2077-0383
dc.identifier.issue19
dc.identifier.urihttps://www.mdpi.com/2077-0383/12/19/6313
dc.identifier.urihttps://hdl.handle.net/11424/294391
dc.identifier.volume12
dc.language.isoeng
dc.relation.ispartofJournal of clinical medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectatrial fibrillation
dc.subjectC-reactive protein
dc.subjectCRP albumin ratio
dc.subjectcryoablation
dc.titleInflammatory markers as predictors of atrial fibrillation recurrence: Exploring the c-reactive protein to albumin ratio in cryoablation patients
dc.typearticle
dspace.entity.typePublication
local.avesis.id45accaff-cfdd-4349-bcad-83e7874bef09
local.indexed.atPUBMED
relation.isAuthorOfPublicationee337595-cb57-413d-96e4-6474f4632b7b
relation.isAuthorOfPublication.latestForDiscoveryee337595-cb57-413d-96e4-6474f4632b7b

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