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Imaging Reactive Oxygen Species-Induced Modifications in Living Systems

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dc.contributor.authorYALÇIN, AHMET SUHA
dc.contributor.authorsMaulucci, Giuseppe; Bacic, Goran; Bridal, Lori; Schmidt, Harald H. H. W.; Tavitian, Bertrand; Viel, Thomas; Utsumi, Hideo; Yalcin, A. Suha; De Spirito, Marco
dc.date.accessioned2022-03-10T11:40:33Z
dc.date.available2022-03-10T11:40:33Z
dc.date.issued2016-06
dc.description.abstractSignificance: Reactive Oxygen Species (ROS) may regulate signaling, ion channels, transcription factors, and biosynthetic processes. ROS-related diseases can be due to either a shortage or an excess of ROS. Recent Advances: Since the biological activity of ROS depends on not only concentration but also spatiotemporal distribution, real-time imaging of ROS, possibly in vivo, has become a need for scientists, with potential for clinical translation. New imaging techniques as well as new contrast agents in clinically established modalities were developed in the previous decade. Critical Issues: An ideal imaging technique should determine ROS changes with high spatio-temporal resolution, detect physiologically relevant variations in ROS concentration, and provide specificity toward different redox couples. Furthermore, for in vivo applications, bioavailability of sensors, tissue penetration, and a high signal-to-noise ratio are additional requirements to be satisfied. Future Directions: None of the presented techniques fulfill all requirements for clinical translation. The obvious way forward is to incorporate anatomical and functional imaging into a common hybrid-imaging platform.
dc.identifier.doi10.1089/ars.2015.6415
dc.identifier.eissn1557-7716
dc.identifier.issn1523-0864
dc.identifier.pubmed27139586
dc.identifier.urihttps://hdl.handle.net/11424/220013
dc.identifier.wosWOS:000377210800004
dc.language.isoeng
dc.publisherMARY ANN LIEBERT, INC
dc.relation.ispartofANTIOXIDANTS & REDOX SIGNALING
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIN-VIVO EPR
dc.subject2-PHOTON FLUORESCENT-PROBE
dc.subjectFREE-RADICAL REACTIONS
dc.subjectREDOX STATUS
dc.subjectOXIDATIVE STRESS
dc.subjectNITRIC-OXIDE
dc.subjectHYDROGEN-PEROXIDE
dc.subjectLIVE CELLS
dc.subjectMULTIPHOTON MICROSCOPY
dc.subjectNONINVASIVE ASSESSMENT
dc.titleImaging Reactive Oxygen Species-Induced Modifications in Living Systems
dc.typereview
dspace.entity.typePublication
local.avesis.idf0284ecb-46b2-48e0-8842-bd4ff2f6db75
local.import.packageSS4
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages20
local.journal.quartileQ1
oaire.citation.endPage958
oaire.citation.issue16
oaire.citation.startPage939
oaire.citation.titleANTIOXIDANTS & REDOX SIGNALING
oaire.citation.volume24
relation.isAuthorOfPublication7a2bc583-aab6-43e7-9cc3-0d7a60773409
relation.isAuthorOfPublication.latestForDiscovery7a2bc583-aab6-43e7-9cc3-0d7a60773409

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