Publication: Change in standardized uptake values in delayed 18F-FDG positron emission tomography images in hepatocellular carcinoma
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2018-10-13
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Abstract
Purpose: Delayed 18F-FDG positron emission tomography (PET)
imaging has been associated with improved diagnostic yield in
several malignancies; however, data on the use of delayed imaging in patients with hepatocellular carcinoma (HCC) is scarce. This
study aimed to examine tumoral and background standardized
uptake value (SUV) alterations in dual-phase 18F-FDG PET/CT imaging. Method: Fifty-two HCC cases underwent dual-time-point 18F-FDG PET/CT examination where early and delayed images
were obtained. The maximum and mean standardized uptake
values (SUVmax and SUVmean) of the tumor were determined
for both time points. Similarly, the mean SUV were also determined for background (liver, soft tissue and spleen). Changes in
tumoral and background SUV between early and delayed images were examined. Results: The mean age was 62.0±12.9 years
(range, 20-88 years) and the majority of the patients were male
(86.5%). Tumor SUVs, both tumor SUVmean and tumor SUVmax,
significantly increased at delayed images when compared to
early images (p<0.05). In contrast, the average SUVmean for the
liver, soft tissue and spleen significantly decreased at delayed images (p<0.05). Conclusion: A significant increase in tumor SUV
at delayed images in contrast to a significant decrease in background SUVs suggests that delayed images in HCC may contribute to diagnostic performance through a potential increase
in the contrast between the tumor and background. However,
further studies with larger sample sizes including patients with
benign lesions and different grades of the disease are warranted
to better elucidate the diagnostic contribution as well as the association of delayed imaging values with prognosis.
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Öksüzoğlu K., ÖNEŞ T., ŞAHİN C. Ö., ÖZGÜVEN S., İNANIR S., TUROĞLU H. T., ERDİL T. Y., \"Change in standardized uptake values in delayed 18F-FDG positron emission tomography images in hepatocellular carcinoma\", Annual Congress of the European Association of Nuclear Medicine 2018, Almanya, 13 - 17 Ekim 2018