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Change in standardized uptake values in delayed 18F-FDG positron emission tomography images in hepatocellular carcinoma

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dc.contributor.authorÖNEŞ, TUNÇ
dc.contributor.authorENGÜR, CEREN ÖZGE
dc.contributor.authorÖZGÜVEN, SALİH
dc.contributor.authorTUROĞLU, HALİL TURGUT
dc.contributor.authorERDİL, TANJU YUSUF
dc.contributor.authorsÖksüzoğlu K., ÖNEŞ T., ŞAHİN C. Ö., ÖZGÜVEN S., İNANIR S., TUROĞLU H. T., ERDİL T. Y.
dc.date.accessioned2023-02-28T12:20:35Z
dc.date.available2023-02-28T12:20:35Z
dc.date.issued2018-10-13
dc.description.abstractPurpose: Delayed 18F-FDG positron emission tomography (PET) imaging has been associated with improved diagnostic yield in several malignancies; however, data on the use of delayed imaging in patients with hepatocellular carcinoma (HCC) is scarce. This study aimed to examine tumoral and background standardized uptake value (SUV) alterations in dual-phase 18F-FDG PET/CT imaging. Method: Fifty-two HCC cases underwent dual-time-point 18F-FDG PET/CT examination where early and delayed images were obtained. The maximum and mean standardized uptake values (SUVmax and SUVmean) of the tumor were determined for both time points. Similarly, the mean SUV were also determined for background (liver, soft tissue and spleen). Changes in tumoral and background SUV between early and delayed images were examined. Results: The mean age was 62.0±12.9 years (range, 20-88 years) and the majority of the patients were male (86.5%). Tumor SUVs, both tumor SUVmean and tumor SUVmax, significantly increased at delayed images when compared to early images (p<0.05). In contrast, the average SUVmean for the liver, soft tissue and spleen significantly decreased at delayed images (p<0.05). Conclusion: A significant increase in tumor SUV at delayed images in contrast to a significant decrease in background SUVs suggests that delayed images in HCC may contribute to diagnostic performance through a potential increase in the contrast between the tumor and background. However, further studies with larger sample sizes including patients with benign lesions and different grades of the disease are warranted to better elucidate the diagnostic contribution as well as the association of delayed imaging values with prognosis.
dc.identifier.citationÖksüzoğlu K., ÖNEŞ T., ŞAHİN C. Ö., ÖZGÜVEN S., İNANIR S., TUROĞLU H. T., ERDİL T. Y., \"Change in standardized uptake values in delayed 18F-FDG positron emission tomography images in hepatocellular carcinoma\", Annual Congress of the European Association of Nuclear Medicine 2018, Almanya, 13 - 17 Ekim 2018
dc.identifier.urihttps://link.springer.com/content/pdf/10.1007/s00259-018-4148-3.pdf
dc.identifier.urihttps://hdl.handle.net/11424/287022
dc.language.isoeng
dc.relation.ispartofAnnual Congress of the European Association of Nuclear Medicine 2018
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleChange in standardized uptake values in delayed 18F-FDG positron emission tomography images in hepatocellular carcinoma
dc.typeconferenceObject
dspace.entity.typePublication
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