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Fabrication and characterization of electrospun ellagic acid-loaded Poly (lactic acid)-polyethylene glycol nanofibers for biomedical application

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dc.contributor.authorBİLĞİÇ ALKAYA, DİLEK
dc.contributor.authorAYAZ SEYHAN, SERAP
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorCESUR, SÜMEYYE
dc.contributor.authorsYaşar K., Yamlı R., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O.
dc.date.accessioned2023-03-06T12:07:21Z
dc.date.available2023-03-06T12:07:21Z
dc.date.issued2022-11-25
dc.description.abstractEllagic acid (dilactone of hexahydroxydiphenic acid, 2,3,7,8-tetrahydroxy-1-benzopyran-5,4,3-cde-1-benzopyran-5,10- dione, EA) is one of the natural polyphenolic antioxidants present in numerous fruits (pomegranate, persimmon, raspberry, black raspberry, strawberry, blueberry, peach, plumes, almonds, walnuts, mango kernel), vegetables and nuts to the tune of 100–1900 mg/kg and contributes significantly to the dietary consumption as nutraceuticals or functional foods. EA demonstrates a broad array of biological roles including anti-inflammatory, anti-carcinogenic, anti-fibrosis, anti-diabetic, anti-ulcer, anti-viral, anti-microbial, anti- apoptotic, anti-mutagenic and cardio-, hepato-renal and neuroprotective together with defense against oxidative stress, lipid peroxidation and free radical damage. Because of its multitarget pharmacological properties endowed with multiple mechanisms of action, can serve as an innovative option for several applications, such as the treatment of bacterial infections and diabet. The use of natural compounds without undesired side effects, in tissue engineering applications, is highly preferred compared to chemical drugs. In recent years, many studies have been carried out to produce nanofibrous materials by electrospinning method. Electrospun nanofibers have very large surface area, controllable pore size and tunable drug release profiles. Several biocompatible polymers with excellent biocompatibility and biodegradability including poly ethylenglycol (PEG) and poly lactic acid (PLA) have been widely used for the synthesis of nanofibers using the electrospun technique. In this study, nanofibers were obtained by adding of EA at different concentration into PLA by electrospinning technique. Morphological (SEM), molecular interaction (FT-IR), thermal analysis (DSC), antioxidant activity and physical analysis were carried out after production process. The resulting structures of nanofibers are suitable for biomedical applications.
dc.identifier.citationYaşar K., Yamlı R., Bilğiç Alkaya D., Ayaz Seyhan S., Cesur S., Gündüz O., \"Fabrication and characterization of electrospun ellagic acid-loaded Poly (lactic acid)-polyethylene glycol nanofibers for biomedical application\", 5th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2022), Ankara, Türkiye, 23 - 25 Kasım 2022, ss.1351-1355
dc.identifier.endpage1355
dc.identifier.startpage1351
dc.identifier.urihttps://www.eurasianbiochem.org/bildiri%20taslaklar%C4%B1/Proceeding_Book_EurasianBioChem_2022.pdf
dc.identifier.urihttps://hdl.handle.net/11424/287195
dc.language.isoeng
dc.relation.ispartof5th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2022)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSağlık Bilimleri
dc.subjectMühendislik ve Teknoloji
dc.subjectHealth Sciences
dc.subjectEngineering and Technology
dc.subjectKlinik Tıp (MED)
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectClinical Medicine (MED)
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectPolylactic acid (PLA)
dc.subjectnanofiber
dc.subjectellagic acid
dc.subjectelectrospinning
dc.titleFabrication and characterization of electrospun ellagic acid-loaded Poly (lactic acid)-polyethylene glycol nanofibers for biomedical application
dc.typeconferenceObject
dspace.entity.typePublication
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