Publication: Low dose MK-801 protects against iron-induced oxidative changes in a rat model of focal epilepsy
No Thumbnail Available
Date
1998
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
We have used chemiluminescence measurements to examine the relationship between free radical formation and excitotoxicity in a post-traumatic epilepsy model. For this purpose, seven days after injecting iron in rat brain cortices, we measured luminol- and lucigenin-enhanced chemiluminescence in different brain regions (ipsilateral cortex, contralateral cortex, hypothalamus and hippocampus). In all brain regions (except contralateral cortices) both luminol- and lucigenin-enhanced chemiluminescence were increased in iron-injected group compared to saline-injected control group. These increases returned to control values in iron-injected rats pretreated with MK-801. Our results suggest that both free radicals and excitatory amino acids play important roles in the development of post-traumatic epilepsy and that MK-801 has protective effects against iron-induced chemiluminescence formation.
Description
Keywords
Animals, Rats, Disease Models, Animal, Drug Evaluation, Preclinical, Analysis of Variance, Luminescent Measurements, Electroencephalography, Rats, Sprague-Dawley, Neuroprotective Agents, Dizocilpine Maleate, Epilepsies, Partial, Excitatory Amino Acid Antagonists, Iron