Publication:
Low dose MK-801 protects against iron-induced oxidative changes in a rat model of focal epilepsy

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dc.contributor.authorYALÇIN, AHMET SUHA
dc.contributor.authorsKüçükkaya, B.; Aker, R.; Yüksel, M.; Onat, F.; Yalçin, A. S.
dc.date.accessioned2022-03-15T11:10:16Z
dc.date.available2022-03-15T11:10:16Z
dc.date.issued1998
dc.description.abstractWe have used chemiluminescence measurements to examine the relationship between free radical formation and excitotoxicity in a post-traumatic epilepsy model. For this purpose, seven days after injecting iron in rat brain cortices, we measured luminol- and lucigenin-enhanced chemiluminescence in different brain regions (ipsilateral cortex, contralateral cortex, hypothalamus and hippocampus). In all brain regions (except contralateral cortices) both luminol- and lucigenin-enhanced chemiluminescence were increased in iron-injected group compared to saline-injected control group. These increases returned to control values in iron-injected rats pretreated with MK-801. Our results suggest that both free radicals and excitatory amino acids play important roles in the development of post-traumatic epilepsy and that MK-801 has protective effects against iron-induced chemiluminescence formation.
dc.identifier.doi10.1016/s0006-8993(97)01544-8
dc.identifier.issn0006-8993
dc.identifier.pubmedPMID: 9554983
dc.identifier.urihttps://hdl.handle.net/11424/248635
dc.language.isoeng
dc.relation.ispartofBrain Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnimals
dc.subjectRats
dc.subjectDisease Models, Animal
dc.subjectDrug Evaluation, Preclinical
dc.subjectAnalysis of Variance
dc.subjectLuminescent Measurements
dc.subjectElectroencephalography
dc.subjectRats, Sprague-Dawley
dc.subjectNeuroprotective Agents
dc.subjectDizocilpine Maleate
dc.subjectEpilepsies, Partial
dc.subjectExcitatory Amino Acid Antagonists
dc.subjectIron
dc.titleLow dose MK-801 protects against iron-induced oxidative changes in a rat model of focal epilepsy
dc.typearticle
dspace.entity.typePublication
local.avesis.id7086e592-e2f7-4744-a89d-97e47ada4b09
local.import.packageSS23
local.import.sourcePubMed
local.indexed.atPUBMED
oaire.citation.endPage136
oaire.citation.startPage133
oaire.citation.titleBrain Research
oaire.citation.volume1-2
relation.isAuthorOfPublication7a2bc583-aab6-43e7-9cc3-0d7a60773409
relation.isAuthorOfPublication.latestForDiscovery7a2bc583-aab6-43e7-9cc3-0d7a60773409

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