Publication: Giant intracranial Rosai-Dorfman disease
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Date
2004
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ELSEVIER SCI LTD
Abstract
Rosai-Dorfman disease is a rare, non-neoplastic disease characterized by an unusual proliferation of histiocytic cells. It rarely manifests intracranially, and only 50 cases of intracranial lesions have been reported. We describe an unusual case of a huge, solid mass in the paranasal sinuses, orbits, cavernous sinuses, and suprasellar cisterns. A 29-year-old patient was admitted to our hospital with nasal obstruction and proptosis and visual loss in the right eye. A biopsy was done at another institution and the diagnosis was pseudotumor of orbit. A right-sided cranio-orbitozygomatic craniotomy combined with a right-sided lateral rhinotomy was used to excise the tumor with right orbital exenteration. The histopathological diagnosis was consistent with Rosai-Dorfman disease. The patient underwent postoperative chemotherapy. Involvement of the central nervous system in Rosai-Dorfman disease is rare, but the disease's ability to mimic other pathologies underlines its importance. (C) 2003 Elsevier Ltd. All rights reserved.
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Keywords
cavernous sinus, cranio-orbitozygomatic approach, lateral rhinotomy, Rosai-Dorfman disease, sinus histiocytosis, EXTRANODAL SINUS HISTIOCYTOSIS, CENTRAL-NERVOUS-SYSTEM, MASSIVE LYMPHADENOPATHY, INVOLVEMENT, MENINGIOMA, MANIFESTATIONS, ENTITY, MASSES