Publication:
Effects of pirfenidone on experimental head injury in rats

Simple item page
dc.contributor.authorGÜVENÇ, YAHYA
dc.contributor.authorsBozkurt I., Ozturk Y., GÜNEY G., Arslan B., GÜLBAHAR Ö., GÜVENÇ Y., Senturk S., YAMAN M. E.
dc.date.accessioned2023-02-14T10:33:26Z
dc.date.available2023-02-14T10:33:26Z
dc.date.issued2022-01-01
dc.description.abstractTraumatic brain injury (TBI) continues to be a significant public healthcare concern. Neuroinflammation that occurs in the secondary phase of TBI leads to cognitive and physical dysfunction. A number of therapeutic modalities have been evaluated in an attempt to find a suitable treatment. The only drug approved for the treatment of idiopathic pulmonary fibrosis, pirfenidone, has been evaluated for its antifibrotic, anti-inflammatory, and anti-oxidant properties for various disorders, but this is the first study to examine its effects in an experimental TBI model. Twenty-four Wistar rats were randomly divided into three groups: control, trauma, and pirfenidone. The two latter groups underwent experimental diffuse cortical injury mimicking TBI. Neurological assessment was performed using the Garcia test, histological analysis was performed to examine neuroprotective and anti-inflammatory effects, and biochemical analyses of neuron-specific enolase (NSE), S-100B, caspase-3, and thiobarbituric acid reactive substances were performed. The pirfenidone group had a better Garcia test score (P=0.001), an increased anti-inflammatory effect (P<0.001), and an enhanced neuroprotective effect (P=0.007) along with decreased NSE, S100B, and TBARS levels compared to the trauma group. However, pirfenidone did not show a beneficial effect on caspase-3 levels. Pirfenidone may help decrease mortality and morbidity rates after TBI through its anti-inflammatory and antioxidant effects.
dc.identifier.citationBozkurt I., Ozturk Y., GÜNEY G., Arslan B., GÜLBAHAR Ö., GÜVENÇ Y., Senturk S., YAMAN M. E., "Effects of pirfenidone on experimental head injury in rats", INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, cilt.15, sa.1, ss.20-28, 2022
dc.identifier.endpage28
dc.identifier.issn1936-2625
dc.identifier.issue1
dc.identifier.startpage20
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822207/pdf/ijcep0015-0020.pdf
dc.identifier.urihttps://hdl.handle.net/11424/286222
dc.identifier.volume15
dc.language.isoeng
dc.relation.ispartofINTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectOnkoloji
dc.subjectCerrahi Tıp Bilimleri
dc.subjectPatoloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectBiochemistry
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectOncology
dc.subjectSurgery Medicine Sciences
dc.subjectPathology
dc.subjectLife Sciences
dc.subjectNatural Sciences
dc.subjectONKOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectPATOLOJİ
dc.subjectBiyoloji ve Biyokimya
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectONCOLOGY
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectPATHOLOGY
dc.subjectBIOLOGY & BIOCHEMISTRY
dc.subjectLife Sciences (LIFE)
dc.subjectHistology
dc.subjectPathology and Forensic Medicine
dc.subjectBiochemistry (medical)
dc.subjectPirfenidone
dc.subjecttraumatic brain injury
dc.subjectneuroprotective
dc.subjectanti-inflammatory
dc.subjectanti-oxidant
dc.subjectNEURON-SPECIFIC ENOLASE
dc.subjectPROTEIN
dc.titleEffects of pirfenidone on experimental head injury in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.ided2160ff-9b05-4ddc-9b3a-da191dbdb846
local.indexed.atWOS
local.indexed.atPUBMED
relation.isAuthorOfPublication2d32e900-06c6-42e9-a4c2-1340958837a3
relation.isAuthorOfPublication.latestForDiscovery2d32e900-06c6-42e9-a4c2-1340958837a3

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
4.pdf
Size:
1.18 MB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs