Publication: Effects of pirfenidone on experimental head injury in rats
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Date
2022-01-01
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Abstract
Traumatic brain injury (TBI) continues to be a significant public healthcare concern. Neuroinflammation that occurs in the secondary phase of TBI leads to cognitive and physical dysfunction. A number of therapeutic modalities have been evaluated in an attempt to find a suitable treatment. The only drug approved for the treatment of idiopathic pulmonary fibrosis, pirfenidone, has been evaluated for its antifibrotic, anti-inflammatory, and anti-oxidant properties for various disorders, but this is the first study to examine its effects in an experimental TBI model. Twenty-four Wistar rats were randomly divided into three groups: control, trauma, and pirfenidone. The two latter groups underwent experimental diffuse cortical injury mimicking TBI. Neurological assessment was performed using the Garcia test, histological analysis was performed to examine neuroprotective and anti-inflammatory effects, and biochemical analyses of neuron-specific enolase (NSE), S-100B, caspase-3, and thiobarbituric acid reactive substances were performed. The pirfenidone group had a better Garcia test score (P=0.001), an increased anti-inflammatory effect (P<0.001), and an enhanced neuroprotective effect (P=0.007) along with decreased NSE, S100B, and TBARS levels compared to the trauma group. However, pirfenidone did not show a beneficial effect on caspase-3 levels. Pirfenidone may help decrease mortality and morbidity rates after TBI through its anti-inflammatory and antioxidant effects.
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Tıp, Sağlık Bilimleri, Temel Tıp Bilimleri, Biyokimya, Dahili Tıp Bilimleri, İç Hastalıkları, Onkoloji, Cerrahi Tıp Bilimleri, Patoloji, Yaşam Bilimleri, Temel Bilimler, Medicine, Health Sciences, Fundamental Medical Sciences, Biochemistry, Internal Medicine Sciences, Internal Diseases, Oncology, Surgery Medicine Sciences, Pathology, Life Sciences, Natural Sciences, ONKOLOJİ, Klinik Tıp, Klinik Tıp (MED), PATOLOJİ, Biyoloji ve Biyokimya, Yaşam Bilimleri (LIFE), ONCOLOGY, CLINICAL MEDICINE, Clinical Medicine (MED), PATHOLOGY, BIOLOGY & BIOCHEMISTRY, Life Sciences (LIFE), Histology, Pathology and Forensic Medicine, Biochemistry (medical), Pirfenidone, traumatic brain injury, neuroprotective, anti-inflammatory, anti-oxidant, NEURON-SPECIFIC ENOLASE, PROTEIN
Citation
Bozkurt I., Ozturk Y., GÜNEY G., Arslan B., GÜLBAHAR Ö., GÜVENÇ Y., Senturk S., YAMAN M. E., "Effects of pirfenidone on experimental head injury in rats", INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, cilt.15, sa.1, ss.20-28, 2022