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The role of free vitamin D and vitamin D binding protein in SARS‐Cov‐2 infection in children

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dc.contributor.authorUS, MAHMUT CANER
dc.contributor.authorsUs M. C.
dc.date.accessioned2023-11-02T10:49:41Z
dc.date.available2023-11-02T10:49:41Z
dc.date.issued2023-10-01
dc.description.abstractBackground: Many studies have discussed the effects of serum vitamin D deficiency in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients. This study aimed to investigate the relationship between SARS-CoV-2 infection severity and free vitamin D (FVD) and bioavailable vitamin D (BAVD) levels in children. Methods: A prospective case–control study design was used. Participants were divided into three groups based on the World Health Organization COVID-19 Clinical Progression Scale. Serum 25-hydroxyvitamin D (ng/mL), albumin (g/L), and vitamin D binding protein (ng/mL) levels were evaluated to investigate the relationship between disease severity and FVD and BAVD levels. Results: In total, 82 participants were included in the study. Of those, 24.4% were uninfected (n=20), 50% had a mild case of SARS-CoV-2 (n=41), and 25.6% had a moderate case (n=21). There was a statistically significant difference in FVD and BAVD levels between the groups (p=0.026). Median FVD (p=0.007, Cohen's d=0.84) and BAVD (p=0.007, Cohen's d=0.86) levels were significantly higher in the mild group compared to the moderate group. FVD and BAVD metabolites were moderately positively correlated with lymphocyte counts (FVD: r=0.437, p<0.001; BAVD: r=0.439, p<0.001). Conclusions: This is the first study to demonstrate a relationship between SARSCoV-2 symptom severity and FVD and BAVD levels. The relationship between FVD and BAVD levels and lymphocyte counts could play an important role in symptom severity and should be evaluated in further studies.
dc.identifier.citationUs M. C., "The role of free vitamin D and vitamin D binding protein in SARS‐Cov‐2 infection in children", PEDIATRICS INTERNATIONAL, cilt.65, sa.1, ss.1-9, 2023
dc.identifier.doi10.1111/ped.15680
dc.identifier.endpage9
dc.identifier.issn1328-8067
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.1111/ped.15680
dc.identifier.urihttps://hdl.handle.net/11424/294587
dc.identifier.volume65
dc.language.isoeng
dc.relation.ispartofPEDIATRICS INTERNATIONAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSağlık Bilimleri
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectClinical Medicine (MED)
dc.subjectchild
dc.subjectSARS-COV-2
dc.subjectvitamin D
dc.subjectvitamin D binding protein
dc.subjectvitamin D deficiency
dc.titleThe role of free vitamin D and vitamin D binding protein in SARS‐Cov‐2 infection in children
dc.typearticle
dc.type.subanimation
dspace.entity.typePublication
local.avesis.ide306fcec-70a0-4a81-af4d-88639b0af617
local.indexed.atPUBMED
relation.isAuthorOfPublication95417eae-407e-4fce-9e80-83de255e2745
relation.isAuthorOfPublication.latestForDiscovery95417eae-407e-4fce-9e80-83de255e2745

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