Publication: Can alfentanil or diltiazem prevent myocardial ischemia due to trachcal intubation?
Loading...
Files
Date
1999-01-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objective: The aim of this study is to evaluate the
efficacy of alfentanil and diltiazem to attenuate the
ca rd io v a s c u la r responses to laryn g o sco p y and
tracheal intubation and their effects on the occurrance
of m yocardial ischem ia in patients with coronary artery
disease.
Methods: Tw enty eight patients A SA ll-lll, 40-80 years
old, scheduled for elective abdom inal surgery were
random ly assigned into three groups. A nesthesia was
induced with 0.2 m g/kg etom idate and 1.5 m g/kg
succinylcholine i.v. in all patients. In group I (n=10) 15
pg/kg alfentanil i.v. and in group II (n=10) 0.2 m g/kg
diltiazem i.v. w ere adm inistered 2 m inutes before
la ryn g o sco p y. In g roup III (n=8) (control) no
m edication w as adm inistered. Systolic, diastolic, mean
arterial pressure, heart rate, rate-pressure product and
ST segm ent changes in Dll and V5 leads w ere
recorded before and after induction at 1., 3., 5. m inutes
of intubation.
Results: M ean arterial pressure was significantly
lower in the alfentanil and diltiazem group 1 m inute
after intubation. T here w as no significant difference in
heart rate betw een groups. R ate-pressure product was
greater than 11000 in all patients of diltiazem and
control groups and in 9 patients of alfentanil group.
Conclusion: Although 0.2 m g/kg diltiazem and 15
p g /kg a lfe n ta n il i.v. a tte n u a te d the hyp e rte n sive
response to tracheal intubation, they w ere found to be
ineffective in decreasing the incidence of m yocardial
ischem ia in coronary artery disease.
K e y W o r d s : M yocardial ischem ia, alfentanil,
d iltia ze m . T ra ch e a l intubation, hem odynam ic
response.
Description
Keywords
Tıp, Sağlık Bilimleri, Temel Tıp Bilimleri, Biyoistatistik ve Tıp Bilişimi, Cerrahi Tıp Bilimleri, Medicine, Health Sciences, Fundamental Medical Sciences, Biostatistics and Medical Informatics, Surgery Medicine Sciences, Klinik Tıp (MED), Klinik Tıp, CERRAHİ, TIBBİ BİLİŞİM, TIP, GENEL & DAHİLİ, Clinical Medicine (MED), CLINICAL MEDICINE, SURGERY, MEDICAL INFORMATICS, MEDICINE, GENERAL & INTERNAL, Genel Sağlık Meslekleri, Patofizyoloji, Temel Bilgi ve Beceriler, Değerlendirme ve Teşhis, Cerrahi, Dahiliye, Tıbbi Bilişim, Aile Sağlığı, Tıp (çeşitli), Genel Tıp, General Health Professions, Pathophysiology, Fundamentals and Skills, Assessment and Diagnosis, Surgery, Internal Medicine, Health Informatics, Family Practice, Medicine (miscellaneous), General Medicine, M yocardial ischem ia, alfentanil, d iltia ze m . T ra ch e a l intubation, hem odynam ic response
Citation
Ay B., Eti Z., Yaycı A., Tezcan H., Bekiroğlu G. N., Göğüş Y., "Can alfentanil or diltiazem prevent myocardial ischemia due to trachcal intubation?", Marmara Medical Journal, cilt.12, sa.1, ss.7-10, 1999