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Increased D-dimer is associated with disease progression and increased mortality in Turkish COVID-19 patients

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dc.contributor.authorMERCANCI, ZEYNEP
dc.contributor.authorILGIN, CAN
dc.contributor.authorOLGUN YILDIZELİ, ŞEHNAZ
dc.contributor.authorKOCAKAYA, DERYA
dc.contributor.authorBALCAN, MEHMET BARAN
dc.contributor.authorKARAKURT, SAİT
dc.contributor.authorERYÜKSEL, SEMİHA EMEL
dc.contributor.authorsMercanci Z., ILGIN C., Yildizeli S. O., KOCAKAYA D., Balcan B., Sengel B. E., KARAKURT S., Eryuksel E.
dc.date.accessioned2023-07-06T13:09:53Z
dc.date.available2023-07-06T13:09:53Z
dc.date.issued2023-05-31
dc.description.abstractObjective: Coagulopathy is thought to play an important role in the development of severe COVID-19. High D-dimer levels have been reported in Chinese cohort studies. However, ethnicity has significant implications for thrombotic risk. Our aim in this study is to determine the effect of D-dimer measurements on disease prognosis and mortality in Turkish patients with COVID-19. Patients and Methods: The study was designed retrospectively. Patients over the age of 18 who were admitted to our hospital were included in the study. Results: The study included 226 patients. According to the World Health Organization staging, 75(33.2%) patients, according to the staging of Siddiqi et al., 67 (29.7%) patients progressed. In the ROC analysis performed to predict mortality, AUC value for D-dimer was found to be 82.25% (95%CI 74.8%-89.71%). When the cut-off value for D-dimer was accepted as ≥3.25mg/L, specificity was 94.15%, correctly classified rate 88.5%, positive likelihood ratio as (LR):5.69, negative LR:0.71. Conclusion: As a result, similar to the Chinese cohorts, elevated D-dimer measurements increase disease progression and mortality in Turkish patients with COVID-19. D-dimer levels of 3.25 mg/L and above, strongly determine the risk of increased mortality in the Turkish Caucasian ethnic group.
dc.identifier.citationMercanci Z., ILGIN C., Yildizeli S. O., KOCAKAYA D., Balcan B., Sengel B. E., KARAKURT S., Eryuksel E., "Increased D-dimer is associated with disease progression and increased mortality in Turkish COVID-19 patients", Marmara Medical Journal, cilt.36, sa.2, ss.175-181, 2023
dc.identifier.doi10.5472/marumj.1302440
dc.identifier.endpage181
dc.identifier.issn1019-1941
dc.identifier.issue2
dc.identifier.startpage175
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85161714690&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/290894
dc.identifier.volume36
dc.language.isoeng
dc.relation.ispartofMarmara Medical Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectGenel Tıp
dc.subjectGeneral Medicine
dc.subjectCOVID-19
dc.subjectD-dimer
dc.subjectEthnicity
dc.subjectMortality
dc.subjectCOVID-19
dc.subjectD-dimer
dc.subjectMortality
dc.subjectEthnicity
dc.titleIncreased D-dimer is associated with disease progression and increased mortality in Turkish COVID-19 patients
dc.typearticle
dspace.entity.typePublication
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