Publication: Increased D-dimer is associated with disease progression and increased mortality in Turkish COVID-19 patients
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Date
2023-05-31
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Abstract
Objective: Coagulopathy is thought to play an important role in the development of severe COVID-19. High D-dimer levels have been reported in Chinese cohort studies. However, ethnicity has significant implications for thrombotic risk. Our aim in this study is to determine the effect of D-dimer measurements on disease prognosis and mortality in Turkish patients with COVID-19. Patients and Methods: The study was designed retrospectively. Patients over the age of 18 who were admitted to our hospital were included in the study. Results: The study included 226 patients. According to the World Health Organization staging, 75(33.2%) patients, according to the staging of Siddiqi et al., 67 (29.7%) patients progressed. In the ROC analysis performed to predict mortality, AUC value for D-dimer was found to be 82.25% (95%CI 74.8%-89.71%). When the cut-off value for D-dimer was accepted as ≥3.25mg/L, specificity was 94.15%, correctly classified rate 88.5%, positive likelihood ratio as (LR):5.69, negative LR:0.71. Conclusion: As a result, similar to the Chinese cohorts, elevated D-dimer measurements increase disease progression and mortality in Turkish patients with COVID-19. D-dimer levels of 3.25 mg/L and above, strongly determine the risk of increased mortality in the Turkish Caucasian ethnic group.
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Tıp, Sağlık Bilimleri, Temel Tıp Bilimleri, Medicine, Health Sciences, Fundamental Medical Sciences, Klinik Tıp (MED), Klinik Tıp, TIP, GENEL & DAHİLİ, Clinical Medicine (MED), CLINICAL MEDICINE, MEDICINE, GENERAL & INTERNAL, Genel Tıp, General Medicine, COVID-19, D-dimer, Ethnicity, Mortality, COVID-19, D-dimer, Mortality, Ethnicity
Citation
Mercanci Z., ILGIN C., Yildizeli S. O., KOCAKAYA D., Balcan B., Sengel B. E., KARAKURT S., Eryuksel E., "Increased D-dimer is associated with disease progression and increased mortality in Turkish COVID-19 patients", Marmara Medical Journal, cilt.36, sa.2, ss.175-181, 2023