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Clinical and biochemical effects of smoking on non-surgical periodontal treatment in grade III stage C periodontitis patients

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dc.contributor.authorDOĞAN, BAŞAK
dc.contributor.authorsArıkan V., Görgülü N. G., Doğan B.
dc.date.accessioned2023-03-29T07:00:13Z
dc.date.available2023-03-29T07:00:13Z
dc.date.issued2023-03-01
dc.description.abstractObjective: The purpose of this study was to evaluate the effect of smoking on clinical parameters and the serum and saliva levels of RANKL, OPG, and IL-34 in periodontitis stage III grade C (III-C) patients after non-surgical periodontal treatment (NSPT). Methods: A total of 60 subjects, 40 periodontitis-III-C patients (20 smokers and 20 non-smokers) and 20 non-smoker periodontally healthy individuals, were included. All clinical periodontal parameters were recorded, and unstimulated saliva and serum samples were collected from all patients at baseline, but at 1 and 3 months only from periodontitis patients (N=40). Saliva and serum levels of RANKL, OPG, and IL-34 were analyzed by ELISA. Results: At baseline only whole mouth probing depth (PD) and percent of sites with PD>5mm were higher in smokers than non-smoker periodontitis patients (p<.05). All periodontal measurements significantly improved in both periodontitis groups after NSPT (p<.001). After NSPT, the reduction in gingival index (GI), bleeding on probing (BOP), and mean PD in sites initially PD≥5mm were lower in smokers than nonsmoker periodontitis patients (p>.05). Only saliva IL-34 levels were higher in all-periodontitis patients than healthy individuals (p=.001) and decreased in both periodontitis groups after NSPT (p<.05). Moreover, elevated serum RANKL level was detected in smokers compared to nonsmoker periodontitis or healthy ones at baseline (p<.05). Serum RANKL levels exhibited no change after NSPT in either periodontitis groups. Conclusions: The smokers are less responsive to NSPT, and saliva IL-34 can be a potential inflammatory marker of periodontitis-III-C. Moreover, high serum RANKL levels are associated with smoking.
dc.identifier.citationArıkan V., Görgülü N. G., Doğan B., "Clinical and Biochemical Effects of Smoking on Non-Surgical Periodontal Treatment in Grade III Stage C Periodontitis Patients", CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.13, sa.1, ss.218-227, 2023
dc.identifier.doi10.33808/clinexphealthsci.1128101
dc.identifier.endpage227
dc.identifier.issn2459-1459
dc.identifier.issue1
dc.identifier.startpage218
dc.identifier.urihttps://dergipark.org.tr/en/pub/clinexphealthsci/issue/76398/1128101
dc.identifier.urihttps://hdl.handle.net/11424/287976
dc.identifier.volume13
dc.language.isoeng
dc.relation.ispartofCLINICAL AND EXPERIMENTAL HEALTH SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiş Hekimliği
dc.subjectKlinik Bilimler
dc.subjectPedodonti
dc.subjectSağlık Bilimleri
dc.subjectDentistry
dc.subjectClinical Sciences
dc.subjectPedodontics
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectDİŞ HEKİMLİĞİ, ORAL CERRAHİ VE TIP
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectDENTISTRY, ORAL SURGERY & MEDICINE
dc.subjectPeriodontoloji
dc.subjectOrtodonti
dc.subjectAğız Cerrahisi
dc.subjectDiş Hijyeni
dc.subjectDişçilik Hizmetleri
dc.subjectDiş Hekimliği (çeşitli)
dc.subjectPeriodontics
dc.subjectOrthodontics
dc.subjectOral Surgery
dc.subjectDental Hygiene
dc.subjectDental Assisting
dc.subjectDentistry (miscellaneous)
dc.subjectGeneral Dentistry
dc.subjectperiodontitis
dc.subjectsmoking
dc.subjectinterleukin-34
dc.subjectreceptor activator of nuclear factor-kappa B ligand
dc.subjectosteoprotegerin
dc.titleClinical and biochemical effects of smoking on non-surgical periodontal treatment in grade III stage C periodontitis patients
dc.typearticle
dspace.entity.typePublication
local.avesis.ide60a6f0a-0b57-4bac-a5a5-a5c6bf1e329b
local.indexed.atSCOPUS
relation.isAuthorOfPublicationa2569f78-7a2a-4f98-8cc9-d8b67ae56f6d
relation.isAuthorOfPublication.latestForDiscoverya2569f78-7a2a-4f98-8cc9-d8b67ae56f6d

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